摘要
目的基于数据挖掘技术分析专利中药复方治疗痛风性关节炎(GA)的用药规律,为GA的药物研究与新药开发提供参考。方法检索中国专利公布公告网站和中国知网专利数据库中治疗GA的专利中药复方,建立内服中药复方专利数据库,借助古今医案云平台V2.3.7软件进行数据挖掘。结果①共纳入治疗GA的专利中药复方575个,涉及中药674味,使用频次位于前10位的中药依次为牛膝、薏苡仁、土茯苓、黄柏、苍术、甘草、茯苓、威灵仙、萆薢、当归。②中药以温性、平性及寒性为主,且以甘味、苦味、辛味多见,归于肝、脾、肺经者居多。③关联规则分析结果显示,常用药对有黄柏-苍术、黄柏-牛膝、苍术-牛膝、土茯苓-萆薢、土茯苓-苍术、苍术-薏苡仁、萆薢-牛膝、萆薢-苍术等;聚类分析得到3类药物组合,即祛湿化浊、清热解毒、引血下行类,祛风除湿、舒筋活络、利尿消肿类,益气健脾、养血活血、散寒解表类;复杂网络分析得到6味核心中药,即萆薢、土茯苓、薏苡仁、苍术、牛膝、黄柏。结论治疗GA的专利中药复方药物以温性、甘味药物为主,多归肝经,功在清热解毒、祛风湿、利尿通淋,常以四妙方、萆薢渗湿汤、土茯苓萆薢汤等方进行加减。
Objective To analyze the medication patterns of patented Chinese herbal formulas for the treatment of gouty arthritis(GA)using data mining technology,providing references for GA drug research and new drug development.Methods Patented Chinese herbal formulas for GA were retrieved from the website of the People's Republic of China National Intellectual Administration(CNIPA)and the China National Knowledge Infrastructure(CNKI)patent database.A database of oral Chinese herbal patent formulas was established,and data mining was conducted using the Ancient and Modern Medical Records Cloud Platform V2.3.7 software.Results①A total of 575 patented Chinese herbal formulas for treating GA were included,involving 674 Chinese herbs.The top 10 most frequently used herbs were Niuxi(Achyranthis Bidentatae Radix),Yiyiren(Coicis Semen),Tufuling(Smilacis Glabrae Rhizoma),Huangbo(Phellodendri Chinensis Cortex),Cangzhu(Atractylodis Rhizoma),Gancao(Glycyrrhizae Radix et Rhizoma),Fuling(Poria),Weilingxian(Clematidis Radix et Rhizoma),Bixie(Dioscoreae Hypoglaucae Rhizoma),and Danggui(Angelicae Sinensis Radix).②The herbs were mainly warm,neutral,and cold in nature,with sweet,bitter,and pungent flavors being predominant.Most herbs were attributed to the liver,spleen,and lung meridians.③Association rule analysis showed commonly used herb pairs such as Huangbo(Phellodendri Chinensis Cortex)—Cangzhu(Atractylodis Rhizoma),Huangbo(Phellodendri Chinensis Cortex)—Niuxi(Achyranthis Bidentatae Radix),Cangzhu(Atractylodis Rhizoma)—Niuxi(Achyranthis Bidentatae Radix),Tufuling(Smilacis Glabrae Rhizoma)—Bixie(Dioscoreae Hypoglaucae Rhizoma),Tufuling(Smilacis Glabrae Rhizoma)—Cangzhu(Atractylodis Rhizoma),Cangzhu(Atractylodis Rhizoma)—Yiyiren(Coicis Semen),Bixie(Dioscoreae Hypoglaucae Rhizoma)—Niuxi(Achyranthis Bidentatae Radix),and Bixie(Dioscoreae Hypoglaucae Rhizoma)—Cangzhu(Atractylodis Rhizoma).Cluster analysis identified three categories of herb combinations:category one for dampness-eliminating and turbidity-resolving,heat-
作者
钱爱
黄传兵
李明
程园园
朱雅文
胡可心
QIAN Ai;HUANG Chuanbing;LI Ming;CHENG Yuanyuan;ZHU Yawen;HU Kexin(Center for Xin'an Medicine and Moderization of Traditional Chinese Medicine of IHM,The First Affiliated Hospital of Anhui University of Chinese Medicine,Hefei,Anhui 230031,China)
出处
《上海中医药杂志》
CSCD
2024年第12期16-21,共6页
Shanghai Journal of Traditional Chinese Medicine
基金
安徽省中医药管理局中医优势专科建设项目(皖中医药服务秘[2022]34号)
安徽省卫健委安徽省卫生健康科研项目重点项目(AHWJ2022a005)
安徽省科技厅安徽省临床医学研究转化专项(202304295107020114)
安徽省教育厅安徽省高校自然科学研究基金重点项目(KJ2021A0556)
合肥综合性国家科学中心大健康研究院新安医学与中医药现代化研究所专项(2023CXMMTCM004)。
关键词
痛风性关节炎
数据挖掘
中药复方
用药规律
专利
gouty arthritis
data mining
traditional Chinese medicine compound
medication pattern
patent
