摘要
去甲乌药碱(Higenamine,HG)是最初从乌头中分离得到的一种苄基异喹啉类生物碱。HG的药理活性主要表现在强心作用、舒张血管、抗血栓、减轻心肌缺血/再灌注损伤、抗氧化、抗炎、免疫调节、抗肿瘤等方面,对心力衰竭、休克、关节炎、缺血/再灌注损伤、抑郁症及肿瘤等多种疾病表现出潜在的治疗作用。加强对HG药理活性及作用机制研究,促进其新药开发和临床应用转化具有重要意义。
Higenamine(HG)is a benzyl isoquinoline alkaloid,which was originally isolated from aconite.The pharmacological activity of HG is mainly manifested in cardiotonic effect,vasodilation,antithrombotic effect,alleviation of myocardial ischemia/reperfusion injury,antioxidant,anti-inflammatory,immune regulation,anti-tumor,etc.HG shows potential therapeutic effects on heart failure,shock,arthritis,ischemia/reperfusion injury,depression,and tumors.It is an important issue to strengthen the research on the pharmacological activity and mechanism of HG,which is of great significance for promoting new drug development and clinical application transformation of HG.
作者
刘欣雅
林玉婷
姚娇
艾启迪
杨岩涛
陈乃宏
阳松威
陈畅
LIU Xinya;LIN Yuting;YAO Jiao;AI Qidi;YANG Yantao;CHEN Naihong;YANG Songwei;CHEN Chang(College of Pharmacy,Hunan University of Chinese Medicine,Changsha 410208 Hunan,China;Hunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces,Changsha 410208 Hunan,China;Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China)
出处
《中药新药与临床药理》
CAS
CSCD
北大核心
2024年第12期1952-1956,共5页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
国家自然科学基金项目(82304750,U2202214)
湖南省自然科学基金青年项目(2022JJ40313,2021JJ30512)
湖南省中医药管理局科研基金项目(B2023139)
湖南中医药大学中药学一流学科项目[校行科字(2018)3号]
湖南省大学生创新创业训练计划项目(S202210541072)。
关键词
去甲乌药碱
乌头
药理活性
作用机制
研究进展
Higenamine
aconite
pharmacological activity
mechanism
research progress
