摘要
目的:探讨急性心肌梗死(AMI)患者血清肿瘤坏死因子受体相关因子6(TRAF6)和组蛋白去乙酰化酶3(HDAC3)水平与冠状动脉病变程度和预后的相关性。方法:选取麻城市中医医院2019年7月~2020年12月收治的122例AMI患者,根据Gensini评分将其分为低分组(n=73,<20分)和高分组(n=49,≥20分)。采用Pearson法分析血清TRAF6和HDAC3水平与Gensini评分的相关性。根据住院28 d内的生存情况,分为生存组(n=85)和死亡组(n=37);采用Cox回归模型分析AMI患者28d内死亡的影响因素;受试者工作特征(ROC)曲线分析TRAF6和HDAC3对AMI患者28d内死亡的预测效能。结果:高分组患者血清TRAF6[(6.01±2.39)μg/ml比(5.06±1.74)μg/ml,P=0.012]和HDAC3水平[(4.14±1.94)ng/ml比(2.87±1.37)ng/ml,P<0.001]显著高于低分组。Pearson相关分析显示,血清TRAF6、HDAC3水平均与Gensini评分呈正相关(r=0.879、0.837,P均<0.001)。死亡组血清TRAF6[(6.89±1.67)μg/ml比(4.81±1.24)μg/ml,P<0.001]和HDAC3水平[(5.37±1.77)ng/ml比(2.52±0.76)ng/ml,P<0.001]均显著高于生存组。Cox回归分析显示,Gensini评分[HR=1.857,95%CI 1.259~2.737,P=0.001]、TRAF6[HR=1.659,95%CI 1.083~2.543,P=0.022]、HDAC3[HR=1.779,95%CI 1.192~2.653,P=0.004]均是AMI患者28d内死亡的独立危险因素。ROC曲线分析显示,TRAF6、HDAC3及二者联合预测AMI患者28d内死亡的AUC分别为0.862、0.859、0.971,二者联合的AUC显著高于TRAF6和HDAC3单独检测(Z=2.535、2.032,P=0.011、0.042)。结论:AMI患者血清TRAF6和HDAC3的水平与冠状动脉病变程度及预后密切相关,二者联合检测对AMI患者的预后有较好的预测价值。
Objective:To investigate the association of serum levels of tumor necrosis factor receptor-related factor 6(TRAF6)and histone deacetylase 3(HDAC3)with severity of coronary artery disease and prognosis in patients with acute myocardial infarction(AMI).Methods:A total of 122 AMI patients admitted Macheng Traditional Chinese Medicine Hospital between July 2019 and December 2020 were selected,divided into low score group(n=73,<20 points)and high score group(n=49,≥20 points)according to Gensini score.Association of serum levels of TRAF6 and HDAC3 with Gensini score was analyzed by Pearson method.According to survival condition during hospitalization within 28d,they were divided into survival group(n=85)and death group(n=37).Cox regression model was used to analyze the influencing factors for death within 28d in AMI patients;receiver operating characteristic(ROC)curve was used to analyze the predictive efficacy of TRAF6 and HDAC3 for death within 28d in AMI patients.Results:Patients in high score group had significant higher serum levels of TRAF6[(6.01±2.39)μg/ml vs.(5.06±1.74)μg/ml,P=0.012]and HDAC3[(4.14±1.94)ng/ml vs.(2.87±1.37)ng/ml,P<0.001]compared with low score group.Pearson correlation analysis indicated that serum levels of TRAF6 and HDAC3 were positively correlated with Gensini score(r=0.879,0.837,P<0.001 all).Patients in death group had significant higher serum levels of TRAF6[(6.89±1.67)μg/ml vs.(4.81±1.24)μg/ml,P<0.001]and HDAC3[(5.37±1.77)ng/ml vs.(2.52±0.76)ng/ml,P<0.001]compared with those in survival group.Cox regression analysis indicated that Gensini score[HR=1.857,95%CI 1.259~2.737,P=0.001],TRAF6[HR=1.659,95%CI 1.083~2.543,P=0.022],HDAC3[HR=1.779,95%CI 1.192~2.653,P=0.004]were independent risk factors for death within 28d in AMI patients.ROC curve analysis indicated that AUC of TRAF6,HDAC3 and their combination predicting death within 28d in AMI patients was 0.862,0.859 and 0.971 respectively,and AUC of combination was significantly higher than those of TRAF6 and HDAC3 alone(Z=2.535,2.
作者
张浩
徐巧玲
胡文义
熊迎兰
向仕格
范翠瑛
阮小倩
ZHANG Hao;XU Qiao-ling;HU Wen-yi;XIONG Ying-lan;XIANG Shi-ge;FAN Cui-ying;RUAN Xiao-qian(Department of Critical Care Medicine,Macheng Traditional Chinese Medicine Hospital,Huanggang,Hubei,438300,China)
出处
《心血管康复医学杂志》
CAS
2024年第6期729-733,共5页
Chinese Journal of Cardiovascular Rehabilitation Medicine
关键词
心肌梗死
冠状动脉疾病
TNF受体相关因子6
预后
Myocardial infarction
Coronary artery disease
TNF receptor-associated factor 6
Prognosis
