摘要
目的:探讨人乳头瘤病毒(HPV)分型检测联合薄层液基细胞学(TCT)对宫颈癌前病变(CIN)及宫颈癌的鉴别诊断价值。方法:选取2021年1月—2023年6月平顶山市妇幼保健院门诊收治的90例疑似宫颈癌患者作为研究对象。行HPV、TCT检测,以病理学检测结果为金标准。比较HPV、TCT单独及联合检测对宫颈癌的鉴别价值,比较宫颈癌及其癌前病变患者不同病变级、癌症分级、分期的检出准确率。结果:与TCT、HPV单独诊断相比,HPV+TCT联合诊断灵敏度、准确度、阴性预测值较高,漏诊率较低,差异均有统计学意义(χ^(2)=15.403、23.181、15.403、13.510,P<0.05);HPV+TCT联合检测对宫颈癌前病变患者不同病变级别检出准确率高于单独检测,差异有统计学意义(χ^(2)=10.696,P<0.05);HPV+TCT联合检测对宫颈癌患者癌症分级检出准确率高于单独检测,差异有统计学意义(χ^(2)=15.025,P<0.05)。结论:HPV+TCT联合检测能够提高宫颈癌筛查的灵敏度和特异度,降低漏诊率,对宫颈癌及其CIN具有较高的鉴别价值,为早期宫颈疾病筛查提供可靠的参考依据。
Objective:To evaluate the value of HPV typing combined with TCT in the differential diagnosis of cervical precancerous lesions and cervical cancer.Methods:A total of 90 suspected cervical cancer patients admitted to the hospital from January 2021 to June 2023 were selected as the study objects.HPV and TCT tests were performed,and pathological test results were the gold standard.The results of three detection methods were compared with those of pathological tissue biopsy.The differential value of HPV and TCT alone and combined detection in cervical cancer,and the detection accuracy of different lesion grades,cancer grades and stages of cervical cancer and precancerous lesions were compared.Results:The diagnostic accuracy,sensitivity and negative predictive value of HPV+TCT were higher than that of HPV and TCT alone,and the missed diagnosis rate was lower than that of HPV and TCT alone(χ^(2)=15.403,23.181,15.403,13.510;P<0.05).The detection accuracy of HPV+TCT was higher than that of HPV and TCT alone(χ^(2)=10.696,P<0.05).The accuracy of HPV+TCT combined detection was higher than that of HPV and TCT alone in the classification and stage of cervical cancer patients(χ^(2)=15.025,P<0.05).Conclusion:The combined detection of HPV+TCT is of high value in differentiating patients with cervical cancer and cervical precancerous lesions.The combined detection of HPV and TCT can effectively reduce the clinical missed diagnosis rate,and provide reliable reference for early cervical disease screening.
作者
姜旭丰
刘娜娜
Jiang Xufeng;Liu Nana(Department of Pathology,Pingdingshan Maternal and Child Health Hospital,Pingding-shan,Henan,467000,China)
出处
《黑龙江医学》
2024年第23期2881-2883,共3页
Heilongjiang Medical Journal
