摘要
目的探究网络游戏障碍(internet gaming disorder,IGD)青少年静息状态下脑网络的动态功能连接(dynamic function network connectivity,dFNC)特征。方法2021年9月至2023年9月纳入44名青少年IGD患者(IGD组,男/女:38/6)和50名健康对照(HC组,男/女:40/10),所有被试完成了人口统计学问卷、Young网络成瘾量表、非适应性认知量表测评及功能磁共振检查。在Matlab平台上对功能磁共振数据进行预处理,并将预处理后的数据分为64个成分进行组水平上的独立成分分析,通过滑动时间窗技术对得到的18个有效的独立成分进行动态功能连接分析,使用SPSS 22.0统计软件比较IGD组和HC组被试大脑三重网络动态功能连接的差异。结果通过聚类分析发现了4种重复出现的dFNC状态,每个状态表示不同功能网络具有不同的连接强度。状态3表示被试的脑网络整体处于弱功能连接的状态,这种状态最为频繁;其次为状态1,该状态表示被试的执行控制网络(central executive network,CEN)内部呈现出增强的功能连接;状态2表示被试的突显网络(salience network,SN)内部呈现出增强的功能连接;状态4表示被试脑网络的功能连接普遍增强,这种状态最不频繁。对时间属性进行非参数置换检验,结果显示,与HC组相比,IGD组在CEN内部强连接的状态1的时间分数较长(IGD组:0.24±0.19,HC组:0.13±0.15,t=1.19,P<0.05,非参数置换检验)。IGD组时间分数与Young网络成瘾量表评分、游戏时间呈正相关(r=0.418,P=0.003;r=0.515,P=0.004)。与HC组相比,IGD组在状态2时SN内部的岛叶与背侧前扣带皮质之间的功能连接增强(P<0.05,FDR校正),在弱连接的状态3的平均停留时间较长(Z=2.09,P<0.05,非参数置换检验)。结论静息状态下IGD青少年大脑三重网络动态功能连接的差异主要表现为CEN内部强连接、SN内部的岛叶与背侧前扣带皮质之间的功能连接增强,以及整体的功能连接减弱,这可能在青少年IG
ObjectiveTo explore the characteristic of dynamic function network connectivity(dFNC)of resting brain networks in internet gaming disorder(IGD)adolescents.MethodsForty-four adolescent IGD subjects(IGD group,male/female:38/6)and fifty healthy controls(HC group,male/female:40/10)were collected,and the subjects completed demographic questionnaires,Young internet addiction scale(YIAS),Chinese adolescents'maladaptive cognitions scale(CAMAS),and functional magnetic resonance imaging(fMRI)tests.The fMRI data were preprocessed on the Matlab platform,and the preprocessed data was divided into 64 components for group level independent component analysis.The dynamic functional connectivity of obtained 18 effective independent components was analyzed by sliding time window technique,and the difference of dynamic functional connectivity of brain triple network between the IGD group and HC group was compared using SPSS 22.0 software.ResultsFour repeated dFNC states were identified through cluster analysis.Each state indicated that different functional networks had different connection strengths.State 3,the most frequent state,had been indicated that the whole brain network of the subject was in a state of weak functional connectivity.The second frequent state was state 1,which indicated enhanced functional connectivity within the subject's central executive network(CEN).State 2 had been indicated enhanced functional connectivity within the subject's salience network(SN).State 4 had been indicated generally enhanced functional connectivity in the subjects'brain networks,and this state was the least frequent.The results of non-parametric permutation test on the time attribute showed that compared with the HC group,the IGD group had a longer time score(IGD group:0.24±0.19,HC group:0.13±0.15,t=1.19,P<0.05,non-parametric substitution test)for state 1 with strong connectivity within the CEN,which was positively correlated with the YIAS score and game time(r=0.418,P=0.003;r=0.515,P=0.004).Compared with HC group,the functional conne
作者
赵涛
李艳歌
张艺博
吴洁
王瑞琪
吕其炎
李定一
郎艳
Zhao Tao;Li Yange;Zhang Yibo;Wu Jie;Wang Ruiqi;Lyu Qiyan;Li Dingyi;Lang Yan(Department of Psychiatry,First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)
出处
《中华行为医学与脑科学杂志》
CAS
CSCD
北大核心
2024年第11期979-985,共7页
Chinese Journal of Behavioral Medicine and Brain Science
基金
国家自然科学基金(82471962)。
关键词
网络游戏障碍
青少年
独立成分分析
静息态脑网络
动态功能连接
Internet gaming disorder
Adolescents
Independent component analysis
Resting-state brain networks
Dynamic functional connectivity
