摘要
目的探究血清miR-193a-3p、激活转录因子5(ATF5)表达水平与三阴性乳腺癌(TNBC)患者临床病理特征及化疗疗效的相关性。方法选取TNBC患者(研究组)和乳腺良性疾病患者(对照组)各120例,检测研究对象血清miR-193a-3p、ATF5水平,分析血清miR-193a-3p、ATF5与病理特征的关系。根据疗效将TNBC患者分为治疗无效组50例和治疗有效组70例,比较2组miR-193a-3p、ATF5表达水平,分析影响TNBC患者化疗疗效的因素。结果与化疗前相比,化疗后研究组血清miR-193a-3p水平升高,ATF5水平降低(P<0.05)。与对照组相比,化疗前研究组血清miR-193a-3p水平降低,ATF5水平升高(P<0.05)。肿瘤直径≥3 cm、淋巴结转移、组织学分级为中低级、临床分期Ⅲ期、Ki-67>30%者miR-193a-3p表达水平降低,ATF5表达水平升高(P<0.05)。TNBC患者中,与治疗有效组相比,治疗无效组血清miR-193a-3p水平降低,ATF5水平升高(P<0.05)。较低水平的miR-193a-3p、较高水平的ATF5、有淋巴结转移、肿瘤直径≥3 cm、组织学分级为中低级、TNM分期Ⅲ期是影响TNBC患者化疗疗效的危险因素(P<0.05)。结论TNBC患者血清中低水平miR-193a-3p、高水平ATF5均是化疗疗效的危险因素。
Objective To explore the correlation between serum levels of miR-193a-3p,activated transcription factor 5(ATF5),clinicopathological characteristics and chemotherapy efficacy in patients with triple negative breast cancer(TNBC).Methods A total of 120 patients with TNBC admitted to our hospital were collected as the research group.In the same period,120 cases with benign breast disease in our hospital were selected as the control group.Serum levels of miR-193a-3p and ATF5 were detected,and the relationship between them and clinicopathological characteristics were detected in two groups.According to the therapeutic effect,TNBC patients were divided into the treatment ineffective group(n=50)and the treatment effective group(n=70).The expression levels of miR-193a-3p and ATF5 were compared between the two groups,and factors affecting the chemotherapy efficacy of TNBC patients were analyzed.Results Compared with before chemotherapy,the serum miR-193a-3p level increased and ATF5 level decreased in TNBC patients after chemotherapy(P<0.05).Compared with the control group,the serum miR-193a-3p level of TNBC patients decreased in the research group before chemotherapy,and ATF5 level increased(P<0.05).The expression level of miR-193a-3p was lower and the expression level of ATF5 was higher in patients with tumor diameter≥3 cm,lymph node metastasis,low histological grade,clinical stageⅢand Ki-67>30%(P<0.05).In TNBC patients,compared with the treatment effective group,patients in the treatment ineffective group showed a decreased serum miR-193a-3p level and an increased ATF5 level(P<0.05).Lower level of miR-193a-3p,higher level of ATF5,lymph node metastasis,tumor diameter≥3 cm,low histological grade,and TNM stageⅢwere risk factors affecting the efficacy of chemotherapy in TNBC patients(P<0.05).Conclusion Low level of miR-193a-3p and high level of ATF5 in the serum of TNBC patients are risk factors for chemotherapy efficacy.
作者
卢鑫怡
杜伟坡
李景刚
郭芳芳
张晓雷
刘静
LU Xinyi;DU Weipo;LI Jinggang;GUO Fangfang;ZHANG Xiaolei;LIU Jing(Department of Breast,Yellow River Sanmenxia Hospital,Sanmenxia 472000,China;Department of Health Examination,Yellow River Sanmenxia Hospital,Sanmenxia 472000,China)
出处
《天津医药》
CAS
2024年第12期1313-1316,共4页
Tianjin Medical Journal
