摘要
精细化工在高端制造、特种材料和人类健康等方面发挥着重要作用.然而,精细化工反应物料大多具有毒性及易燃易爆性,且已建成工艺通常采用间歇/半间歇操作,自动化水平低,存在生产安全隐患.针对已建成的精细化工工艺流程,通过流程再造实现流程简化、工作物料体积减少、操作方式连续化及本质安全性提升等目标已成为研究热点.基于本课题组的研究工作,本文提出采用超重力强化精细化工反应流程再造策略,基于超重力强化传递速率使之与反应速率相匹配的技术原理,发展了超重力连续化、短流程集成技术,并以氧化、氟化、偶氮化、烷基化以及氯化等工艺为应用实例,阐述了超重力强化反应流程再造的成效.
Fine chemicals have played an important role in fields such as advanced manufacturing,special materials,and human health.However,the materials involved in fine chemical reactions are mostly characterized by toxic,flammable and explosive.Moreover,the operation is usually in batch/semi-batch mode,which brings low level of automation and potential safety risks.For the established fine chemical processes,it has become a research hotspot to achieve the goals of simplifying the process,reducing the amount of working materials,converting into continuous operation mode,and improving inherent safety via process reengineering.Based on the researches of our group,a strategy of process reengineering for fine chemicals production via Higee technology was proposed.According to the principle that the Higee devices can intensify the transfer rate to match the reaction rate,the Higee-intensified integration technology featuring continuity and short process was developed.Case studies were carried out taking oxidation,fluorination,azotization,alkylation,chlorination and other processes as examples to clarify the effects of Higee-intensified process reengineering.
作者
初广文
徐涵卓
罗勇
张亮亮
孙宝昌
邹海魁
陈建峰
Guang-Wen Chu;Han-Zhuo Xu;Yong Luo;Liang-Liang Zhang;Bao-Chang Sun;Hai-Kui Zou;Jian-Feng Chen(Research Center of the Ministry of Education for High Gravity Engineering and Technology,Beijing University of Chemical Technology,Beijing 100029,China;State Key Laboratory of Organic-Inorganic Composites,Beijing University of Chemical Technology,Beijing 100029,China)
出处
《中国科学：化学》
CAS
CSCD
北大核心
2024年第11期1959-1966,共8页
SCIENTIA SINICA Chimica
基金
国家重点研发计划(编号:2021YFC3001102)资助项目。
关键词
超重力
精细化工
流程再造
本质安全性
Higee
fine chemistry industry
process reengineering
inherent safety
