摘要
目的:观察平肝降压膏治疗阴虚阳亢型高血压的临床疗效。方法:将110例阴虚阳亢型原发性高血压2级的病人按照随机数字表法分为两组,对照组予硝苯地平控释片联合阿利沙坦酯片方案降压治疗,治疗组在对照组治疗基础上加服平肝降压膏,疗程为3个月,3个月后比较两组临床疗效,比较两组动态血压、血压变异系数、血脂、动脉粥样硬化指数(AI)及中医症状评分变化情况。结果:治疗组总有效率为94.54%,高于对照组的80.00%(P<0.05)。两组治疗后头晕、头痛、五心烦热评分均较治疗前降低(P<0.05),且治疗组治疗后降低更明显(P<0.05);对照组治疗后腰膝酸软评分较治疗前无明显变化(P>0.05),治疗组治疗后腰膝酸软评分较治疗前降低(P<0.05)。两组治疗后24 h、日间、夜间平均收缩压和舒张压均较治疗前降低(P<0.05),且治疗组治疗后降低更明显(P<0.05)。两组治疗后24 h、日间、夜间收缩压标准差和舒张压标准差均较治疗前降低(P<0.05),且治疗组治疗后降低更明显(P<0.05)。治疗组治疗后总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)均低于对照组(P<0.05),高密度脂蛋白胆固醇(HDL-C)高于对照组(P<0.05)。治疗组治疗后AI较治疗前降低(P<0.05),且治疗组治疗后AI低于对照组(P<0.05)。结论:平肝降压膏可辅助降压,减小血压变异性,拮抗血脂代谢紊乱,控制动脉硬化进展,有效地改善阴虚阳亢型原发性高血压病人的临床症状。
Objective:To observe the effect of Pinggan Jiangya ointment on Yin deficiency and Yang hyperactivity type hypertension.Methods:A total of 110 patients with grade 2 Yin deficiency and Yang hyperactivity of hypertension were divided into two groups according to the random number table method.The control group was treated with nifedipine controlled release tablet combined with alisartan ester table,and the treatment group was treated with Pinggan depressor cream on the basis of the treatment of the control group for 3 months.The clinical efficacy of the two groups were compared after 3 months.The ambulatous blood pressure,blood pressure variation coefficient,blood lipids,atherosclerosis index(AI),and traditional Chinese medicine(TCM)symptom score were compared between the two groups.Results:The total effective rate of the treatment group was 94.54%,which was higher than that of the control group(80.00%,P<0.05).The scores of dizziness,headache and five upset heat in two groups after treatment were lower than those before treatment(P<0.05),and the decrease was more obvious in the treatment group after treatment(P<0.05).There was no significant change in the lumbar and knee tenderness score of the control group after treatment(P>0.05),and that of the treatment group were lower than that before treatment(P<0.05).The mean systolic blood pressure and diastolic blood pressure of 24 h,day and night in both groups were lower than that before treatment(P<0.05),and the decrease was more significant in the treatment group(P<0.05).The standard deviation of systolic blood pressure and diastolic blood pressure in 24 h,day and night after treatment in both groups were lower than those before treatment(P<0.05),and the reduction was more significant in the treatment group(P<0.05).After treatment,total cholesterol(TC),triglyceride(TG)and low density lipoprotein cholesterol(LDL-C)in the treatment group were lower than those in the control group(P<0.05),and high density lipoprotein cholesterol(HDL-C)was higher than that in the control g
作者
李佩玲
邓文浩
黄桂琼
骆青林
陈洪
洪晓华
LI Peiling;DENG Wenhao;HUANG Guiqiong;LUO Qinglin;CHEN Hong;HONG Xiaohua(Huizhou Hospital of Guangzhou University of Chinese Medicine,Huizhou 516000,Guangdong,China)
出处
《中西医结合心脑血管病杂志》
2024年第23期4259-4263,共5页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
基金
国家中医药管理局第七批全国老中医药专家学术经验继承项目,编号:国中医药人教函[2022]76号。
关键词
原发性高血压
平肝降压膏
阴虚阳亢
血压变异性
血脂代谢
动脉硬化
essential hypertension
Pinggan Jiangya ointment
Yin deficiency and Yang hyperactivity
blood pressure variability
lipid metabolism
arteriosclerosis
