摘要
目的:探讨痰热清注射液与常见联合用药患者疑似发生过敏反应之间的关系。方法:收集2018年1月至2023年6月中国人民解放军白求恩国际和平医院和河北省中医药科学院附属医院有痰热清注射液使用记录的患者的病例资料进行嵌套病例对照研究,使用倾向值匹配的方法按照年龄、性别、科室筛选对照组病例,通过抗过敏药物评估疑似过敏反应,利用单因素分析和多因素分析的Logistic回归方法,扩大样本量进行敏感性分析。结果:从痰热清注射液处方用药患者中筛选得到403例作为研究组,多因素Logistic回归分析显示,痰热清注射液与5种药物联合应用会增加过敏反应的风险,分别为头孢曲松(OR=3.476,95%CI=2.473~4.205)、利多卡因(OR=1.462,95%CI=1.136~1.801)、氨溴索(OR=1.225,95%CI=1.013~1.522)、莫西沙星(OR=1.904,95%CI=1.257~2.469)和维生素C(OR=1.436,95%CI=1.107~1.834);而痰热清注射液与头孢硫脒联合应用会降低过敏反应风险(OR=0.711,95%CI=0.562~1.112)。敏感性分析结果与上述结果基本一致。结论:使用痰热清注射液发生疑似过敏反应可能与5种药物(头孢曲松、利多卡因、氨溴索、莫西沙星和维生素C)联合应用有关,临床联合用药时应注意。
OBJECTIVE:To explore the correlation between Tanreqing injection and suspected allergic reactions in patients with common drug combination.METHODS:Case data of patients with Tanreqing injection recorded in Bethune International Peace Hospital of the Chinese People’s Liberation Army and Affiliated Hospital of Hebei University of Traditional Chinese Medicine from Jan.2018 to Jun.2023 were collected for nested case-control study.The control group cases were screened by age,gender and department by using propensity value matching method.Suspected allergic reactions were evaluated by anti-allergic drugs,and sensitivity analysis was conducted by univariate analysis and multivariate Logistic regression analysis with expanded sample size.RESULTS:Totally 403 patients with Tanreqing injection were selected as the study group.Multivariate Logistic regression analysis showed that the combination of Tanreqing injection and five drugs increased the risk of allergic reactions,namely ceftriaxone(OR=3.476,95%CI=2.473-4.205),lidocaine(OR=1.462,95%CI=1.136-1.801),ambroxol(OR=1.225,95%CI=1.013-1.522),moxifloxacin(OR=1.904,95%CI=1.257-2.469)and vitamin C(OR=1.436,95%CI=1.107-1.834);while the combination of Tanreqing injection and ceftiamidine(OR=0.711,95%CI=0.562-1.112)reduced the risk of allergic reactions.The sensitivity analysis results were basically consistent.CONCLUSIONS:The suspected allergic reactions of Tanreqing injection may be related to drug combination of five drugs(ceftriaxone,lidocaine,ambroxol,moxifloxacin and vitamin C),care should be taken in the clinical drug combination.
作者
冯荣伟
张金虎
殷玮
刘婷婷
王文习
FENG Rongwei;ZHANG Jinhu;YIN Wei;LIU Tingting;WANG Wenxi(Dept.of Pharmacy,Bethune International Peace Hospital of the Chinese People’s Liberation Army,Shijiazhuang 050081,China;Dept.of Integrated Traditional Chinese and Western Medicine,Affiliated Hospital of Hebei Academy of Chinese Medical Sciences,Shijiazhuang 050000,China)
出处
《中国医院用药评价与分析》
2024年第11期1352-1354,1359,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
基金
河北省中医药管理局科研计划项目(No.2020264)。
