摘要
目的:本综述旨在论述新型肝脏靶向性Gd-MRI对比剂的设计思路、合成方法及其在分子影像诊断中的应用研究进展,为提升肝脏疾病诊断的精确度提供科学依据。方法:通过文献检索和分析,全面概述了近年来在肝脏靶向性Gd-MRI对比剂领域取得的关键进展和研究动态,包括Gd-EOB-DTPA、Gd-DOTA类配合物等多种开链和环状配体磁共振对比剂的合成方法及其在肝脏显像中的应用效果。结果:新型肝脏靶向性Gd-MRI对比剂通过增强病变组织与正常肝组织之间的对比度,显著提升了对小肝癌的诊断灵敏度和准确度。结论:新型肝脏靶向性Gd-MRI对比剂在肝疾病成像中表现出广阔的应用前景。未来的研究应深入探讨如何增强这些对比剂的安全性、稳定性和靶向性,从而促进其在临床诊疗中的广泛应用。
Objective:This review aims to critically evaluate the innovative design concepts and synthetic strategies of novel liver-targeting Gd-MRI contrast agents in molecular imaging,with the goal of enhancing diagnostic accuracy for liver diseases.Methods:We conducted a comprehensive literature review to summarize the recent advancements and emerging trends in the synthesis of liver-specific Gd-based contrast agents, including Gd-EOB-DTPA, Gd-DOTA, and other open-chain and cyclic ligands, and their applications in hepatic imaging. Results: The use of these targeted contrast agents has shown a significant improvement in the detection of small liver cancers by enhancing the contrast between pathological and normal hepatic tissues. Conclusion: The novel liver-targeting Gd-MRI contrast agents exhibit promising application prospects in liver disease imaging. Future research should focus on optimizing their safety, stability and targeting efficiency to facilitate their widespread adoption in clinical practice and contribute to the improvement of diagnostic and therapeutic strategies.
作者
王红波
胡建林
邹澄
徐东东
王绍波
尚文斌
WANG Hongbo;HU Jianlin;ZOU Cheng;XU Dongdong;WANG Shaobo;SHANG Wenbin(School of Pharmaceutical Sciences&Yunnan Key Laboratory of Pharmacology for Natural Products,Kunming Medical University,Kunming 650500,Yunnan,P.R.China;Yunnan College of Modern Biomedical Industry,Kunming Medical University,Kunming 650500,Yunnan,P.R.China;Department of Nuclear Medicine,The First People’s Hospital of Yunnan Province,Kunming 650032,Yunnan,P.R.China)
出处
《影像科学与光化学》
CAS
2024年第6期535-550,共16页
Imaging Science and Photochemistry
基金
国家自然科学基金地区科学基金项目(22367018)
2024年度云南省重点研发-社会发展专项(争先竞位)项目(202403AC100018)
云南省科技厅-昆明医科大学应用基础研究联合专项面上基金资助项目(202201AY070001-005)
云南省科技厅基础研究专项青年项目(202201AU070135)
云南省天然药物药理重点实验室开放基金重点项目(YKLPNP-K2401)
昆明医科大学有毒药用植物活性成分发现与利用省创新团队(202005AE160004)。
关键词
磁共振对比剂
钆
肝脏
稳定性
弛豫率
magnetic resonance contrast agent
gadolinium
liver
stability
relaxation rate
