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清热解毒胶囊引起中毒性表皮坏死松解症致死1例

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摘要 患者,男,59岁。既往肾病综合征病史1年,规律口服醋酸泼尼松片、阿法骨化三醇软胶囊、碳酸钙咀嚼片治疗,肾病综合征控制稳定,否认遗传病史及药物、食物过敏史。入院前3 d因受凉感冒,出现咽痛、全身燥热,自服清热解毒胶囊0.6 g(2粒)。次日晨起,全身出现散在粟粒样红色疱疹,以手掌、足底为著,无明显疼痛、瘙痒,就诊于当地医院,诊断为药物性皮炎、多形红斑,停用所有服用药物,给予甲泼尼龙琥珀酸钠160 mg、左氧氟沙星0.5 g静脉滴注,每天1次,治疗2 d,期间皮疹面积逐渐增大,并融合成片,局部出现大水疱,部分破溃,同时出现寒战、发热、乏力,最高体温38.9℃,遂于2022年1月6日转入我院。
出处 《临床合理用药杂志》 2024年第34期187-188,共2页 Chinese Journal of Clinical Rational Drug Use
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