摘要
目的:比较甲巯咪唑和丙硫氧嘧啶治疗甲状腺功能亢进症(简称甲亢)的临床效果。方法:选取2023年1—12月广州医科大学附属妇女儿童医疗中心收治的甲亢患者60例进行研究,依据随机数字表法分为对照组与观察组,各30例。观察组给予甲巯咪唑治疗,对照组给予丙硫氧嘧啶治疗。比较两组甲状腺激素水平、肝功能指标、不良反应。结果:治疗后,两组游离三碘甲状腺原氨酸、游离甲状腺素、三碘甲状腺原氨酸水平均低于治疗前,且观察组低于对照组;两组促甲状腺激素水平均高于治疗前,且观察组高于对照组(P<0.05)。治疗后,两组总胆红素、碱性磷酸酶、天冬氨酸氨基转移酶、丙氨酸氨基转移酶均低于治疗前,且观察组低于对照组(P<0.05)。观察组肝脏损伤发生率低于对照组,白细胞计数减少发生率高于对照组(P<0.05);两组不良反应总发生率,差异无统计学意义(P>0.05)。结论:与丙硫氧嘧啶相比,甲巯咪唑治疗甲状腺功能亢进症的临床效果更显著,能够降低甲状腺激素水平,改善肝功能,临床在选择药物时,需要根据患者病情,制定合理的用药方案,保障用药安全。
Objective:To compare the clinical effect of methimazole and propylthiouracil in the treatment of hyperthyroidism(hy-perthyroidism).Methods:A total of sixty patients with hyperthyroidism admitted to Women and Children's Medical Center of Guangzhou Medical University from January 2023 to December 2023 were selected for this study.They were divided into control group and observation group according to random number table method,with thirty cases in each group.The observation group was treated with methimazole and the control group was treated with propylthiouracil.The thyroid hormones,liver function index and adverse reactions were compared between the two groups.Results:After treatment,the levels of free triiodothyronine,free thyrox-ine and triiodothyronine in two groups were lower than before treatment,and the observation group was lower than the control group;the level of thyrotropin in both groups was higher than before treatment,and the observation group was higher than the con-trol group(P<0.05);after treatment,total bilirubin,alkaline phosphatase,aspartate aminotransferase and alanine aminotransferase in 2 groups were lower than before treatment,and observation group was lower than control group(P<0.05);the incidence of liver injury in observation group was lower than that in control group,and the incidence of reduced WBC count was higher than that in control group(P<0.05);there was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:Compared with propylthiouracil,methimazole has a more significant clinical effect in the treatment of hyper-thyroidism,which can reduce thyroid hormone levels and improve liver function.In the clinical selection of drugs,it is necessary to formulate a reasonable medication regimen according to the patient's condition to ensure the safety of medication.
作者
马永成
Ma Yongcheng(Women and Children's Medical Center Affiliated to Guangzhou Medical University,Guangzhou 511300,Guangdong Province,China)
出处
《中国社区医师》
2024年第32期59-61,共3页
Chinese Community Doctors
