摘要
目的探讨复发性自然流产(RSA)患者再妊娠后早期血清微小RNA-146b(miR-146b)、微小RNA-184(miR-184)水平与妊娠结局的关系。方法选取2019年5月至2022年5月沧州市人民医院收治的146例RSA再妊娠患者作为RSA组,选取同期146例身体正常且无流产史的孕妇作为对照组。根据患者妊娠情况,以流产、畸形儿、低体重儿、死胎、产褥出血等为不良妊娠结局,将患者分为不良妊娠结局组(n=49)和正常妊娠结局组(n=97)。比较血清miR-146b、miR-184表达水平,以及不良妊娠结局组和正常妊娠结局组临床资料,采用Pearson法分析血清miR-146b、miR-184水平的相关性,采用Logistic回归分析不良妊娠结局的影响因素,采用受试者工作特征(ROC)曲线分析血清miR-146b、miR-184对不良妊娠结局的预测效能。结果RSA组血清miR-146b低于对照组,miR-184高于对照组(P<0.05)。不良妊娠结局组孕次、舒张压、收缩压均高于正常妊娠结局组,产次低于正常妊娠结局组(P<0.05)。不良妊娠结局组血清miR-146b低于正常妊娠结局组,miR-184高于正常妊娠结局组(P<0.05)。不良妊娠结局组血清miR-146b与miR-184水平呈负相关(r=-0.566,P<0.001)。miR-146b和miR-184均为RSA患者再妊娠后不良妊娠结局的独立影响因素(P<0.05)。血清miR-146b、miR-184联合预测效能高于单独预测(P<0.05)。结论RSA患者血清miR-146b显著下调,miR-184显著上调,两者水平与RSA及RSA患者再妊娠后的不良妊娠结局具有相关性。
Objective To investigate the relationship between early serum levels of microRNA-146b(miR-146b)and microRNA-184(miR-184)and pregnancy outcomes in recurrent spontaneous abortion(RSA)patients with repregnancy.Methods A total of 146 RSA patients who underwent treatment in Cangzhou People′s Hospital from May 2019 to May 2022 were selected as the RSA group,and 146 normal pregnant women with no history of miscarriage were selected as the control group.According to the pregnancy condition of the patients,taking abortion,deformed babies,low birth weight babies,stillbirths,and postpartum bleeding as adverse pregnancy outcomes,the patients were grouped into adverse pregnancy outcome group(n=49)and normal pregnancy outcome group(n=97).The serum miR-146b,miR-184 expression levels,and clinical data in the adverse pregnancy outcome group and the normal pregnancy outcome group were compared.Pearson method was applied to analyze the correlation between serum miR-146b and miR-184 levels.Logistic regression was applied to analyze the influencing factors of adverse pregnancy outcomes.Receiver operating curve(ROC)was applied to analyze the efficacy of serum miR-146b and miR-184 in predicting adverse pregnancy outcomes.Results The serum miR-146b in the RSA group was lower than that in the control group,and miR-184 was higher than that in the control group(P<0.05).The pregnancy frequency,diastolic blood pressure,and systolic blood pressure of patients in the adverse pregnancy outcomes group were significantly higher than those in normal pregnancy outcomes group,while the delivery frequency was significantly lower than those in the normal pregnancy outcomes group(P<0.05).The serum miR-146b level in the adverse pregnancy outcome group was lower than that in the normal pregnancy outcome group,and the miR-184 level was higher than that in the normal pregnancy outcome group(P<0.05).There was a negative correlation between the serum miR-146b and miR-184 levels in patients with adverse pregnancy outcomes(r=-0.566,P<0.001).MiR-146b and miR-
作者
宋艳敏
杨秀梅
刘俊秀
赵媛媛
赵明阳
颛佳
韩哲
SONG Yanmin;YANG Xiumei;LIU Junxiu;ZHAO Yuanyuan;ZHAO Mingyang;ZHUAN Jia;HAN Zhe(Department of Gynaecology,Cangzhou People′s Hospital,Cangzhou 061000,Hebei,China)
出处
《中国性科学》
2024年第11期53-56,共4页
Chinese Journal of Human Sexuality
基金
河北省卫生健康委员会资助项目(20232090)。
