摘要
目的观察小儿肺咳颗粒联合布地奈德治疗儿童咳嗽变异性哮喘的疗效及对机体免疫力的影响。方法选取73例咳嗽变异性哮喘儿童作为研究对象,用随机数字表法分为联合组(n=36)和对照组(n=37)。对照组给予布地奈德治疗,联合组给予小儿肺咳颗粒联合布地奈德治疗。比较2组的临床疗效、不良反应的发生情况、复发率以及治疗前后咳嗽症状、免疫功能、肺功能和炎症指标的水平。结果联合组的总有效率(94.44%)明显高于对照组(75.68%),P<0.05。治疗后,2组的日间、夜间咳嗽症状评分均明显降低,且联合组低于对照组(P<0.05);2组的CD4^(+)、CD4^(+)/CD8^(+)水平明显降低,CD8^(+)水平明显升高,且联合组的改善程度明显优于对照组(P<0.05);2组的第1秒用力呼气容积(forced expiratory volume in first second,FEV_(1))、用力肺活量(forced vital capacity,FVC)、第1秒用力呼气容积占用力肺活量百分比(forced expiratory volume in first second/forced vital capacity,FEV_(1)/FVC)均明显升高,且联合组高于对照组(P<0.05);2组的血清肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白细胞介素-4(interleukin-4,IL-4)水平均明显降低,且联合组低于对照组(P<0.05)。联合组的不良反应发生率(13.89%)与对照组(18.92%)比较差异无统计学意义(P>0.05),联合组的随访期复发率为5.56%,明显低于对照组(27.03%),P<0.05。结论小儿肺咳颗粒联合布地奈德治疗儿童咳嗽变异性哮喘的临床疗效显著,不仅能提高患儿的免疫力,同时能有效缓解患儿的咳嗽症状,降低炎症因子水平,改善肺功能,有效降低复发率。
Objective To explore the efficacy of Xiaoer Feike Granules combined with budesonide on cough variant asthma in children and its influence on immunity.Methods 73 children with cough variant asthma were selected as the study objects,and randomly divided into a combination group(n=36)and a control group(n=37)according to random number table method.The control group was treated with budesonide,while the combination group was treated with Xiaoer Feike Granules additionally.The clinical efficacy,adverse reactions,recurrence rate,cough symptoms,immune function,lung function and inflammatory indices were analyzed and compared between the 2 groups.Results The total effective rate of clinical treatment in the combination group was higher than in the control group(94.44%vs.75.68%,P<0.05).After treatment,the daytime and nighttime cough symptom scores of the both groups were reduced,and the scores of the combination group were lower than that of the control group(P<0.05).The levels of CD4^(+)and CD4^(+)/CD8^(+)in the both groups were significantly decreased,while the levels of CD8^(+)increased(P<0.05),and the improvement of immune function in the combination group was significantly better than that in the control group(P<0.05).The forced expiratory volume in first second(FEV_(1)),forced vital capacity(FVC),and FEV_(1)/FVC levels in the both groups were significantly increased,and the indices in combination group were higher than in the control group(P<0.05).The serum tumor necrosis factor-α(TNF-α),interleukin-4(IL-4)of children in the 2 groups decreased,and the serum TNF-α,IL-4 of the combination group were lower than in the control group(P<0.05).The adverse reactions in the combination group(13.89%)was not significantly different from that in the control group(18.92%),P>0.05.The recurrence rate during the follow-up period in the combination group of children(5.56%)was significantly lower than in the control group(27.03%),P<0.05.Conclusion Xiaoer Feike Granules combined with budesonide in the treatment of children with cou
作者
万光平
杜华伟
刘杰
WAN Guangping;DU Huawei;LIU Jie(Department of Pediatrics,Meishan People’s Hospital,Meishan 620000,China)
出处
《西北药学杂志》
CAS
2024年第6期109-114,共6页
Northwest Pharmaceutical Journal
基金
四川省医学科研课题计划项目(编号:S18058)。
