摘要
目的探讨老年急性脑梗死(ACI)患者予以血管内介入取栓+阿替普酶静脉溶栓治疗的效果。方法回顾性分析80例老年ACI患者的临床资料,按治疗方法差异分为对照组(阿替普酶静脉溶栓)、观察组(联合血管内介入取栓),每组40例。对比两组临床疗效、血管再通率、神经功能[美国国家卫生研究院卒中量表(NIHSS)]、日常生活能力[日常生活活动能力(ADL)]及血管收缩期峰流速。结果观察组血管再通率(90.00%)、临床总有效率(97.50%)均高于对照组的10.00%、75.00%(P<0.05);治疗后,观察组NIHSS评分(19.96±2.48)分低于对照组的(22.60±3.02)分,ADL评分(84.89±6.20)分高于对照组的(78.79±5.78)分(P<0.05);治疗后,观察组颈总动脉(110.08±12.05)cm/s、颈内动脉(112.17±18.25)cm/s、椎动脉(112.16±17.60)cm/s、基底动脉(116.63±8.69)cm/s的收缩期峰流速水平均低于对照组的(140.06±18.87)、(218.87±20.46)、(200.03±20.04)、(202.03±12.05)cm/s(P<0.05)。结论老年ACI患者实施血管内介入取栓+阿替普酶静脉溶栓治疗疗效显著,可提升血管再通率,改善神经功能、日常生活能力,降低血管再狭窄发生风险。
Objective To explore the effect of intravascular thrombectomy combined with alteplase intravenous thrombolysis in the treatment of acute cerebral infarction(ACI)in the elderly and its impact on patients'neurological function.Methods A retrospective analysis was conducted on the clinical data of 80 elderly ACI patients,who were divided into a control group(intravenous thrombolysis with alteplase)and an observation group(combined with endovascular thrombectomy)according to different treatment methods,with 40 cases in each group.Compare the clinical efficacy,vascular recanalization rate,neurological function[National Institutes of Health Stroke Scale(NIHSS)],activities of daily living(ADL),and peak systolic velocity between two groups.Results The vascular recanalization rate(90.00%)and clinical total effective rate(97.50%)in the observation group were higher than the control group(10.00%,75.00%,P<0.05);After treatment,the NIHSS score(19.96±2.48)of the observation group was lower than the control group(22.60±3.02),and the ADL score(84.89±6.20)was higher than the control group(78.79±5.78)(P<0.05);After treatment,the peak systolic velocity levels of the common carotid artery(110.08±12.05)cm/s,internal carotid artery(112.17±18.25)cm/s,vertebral artery(112.16±17.60)cm/s,and basilar artery(116.63±8.69)cm/s in the observation group were lower than those in the control group(140.06±18.87),(218.87±20.46),(200.03±20.04),and(202.03±12.05)cm/s(P<0.05).Conclusion The implementation of intravascular thrombectomy combined with alteplase intravenous thrombolysis has significnat efficacy on elderly patients with ACI,which can improve vascular recanalization rate,improve neurological function and daily living ability,and reduce the risk of vascular restenosis.
作者
周芳贵
ZHOU Fang-gui(Department of Neurology,Jian'ou Municipal Hospital,Jian'ou 353100,China)
出处
《中国现代药物应用》
2024年第21期85-88,共4页
Chinese Journal of Modern Drug Application
关键词
老年
急性脑梗死
阿替普酶
血管内介入取栓
静脉溶栓
神经功能
Old age
Acute cerebral infarction
Alteplase
Intravascular thrombectomy
Intravenous thrombolysis
Neurological function
