摘要
心肌缺血是临床常见病,中医药在缓解心肌缺血损伤的防治中表现出良好的效果,其作用机制是研究热点。缝隙连接蛋白43(Cx43)是介导相邻心肌细胞间电耦合的缝隙连接(GJ)的主要成分。在心肌缺血时,心肌细胞Cx43表达和磷酸化水平及空间分布的异常,可通过影响GJ功能参与心肌缺血损伤发生发展。目前中药治疗心肌缺血疾病研究较多的集中在中药单体及有效成分和复方方面,归纳总结中药单体及有效成分(主要有龙血竭总黄酮、当归黄酮、乌腺金丝桃总黄酮、银杏黄酮、三七总皂苷、金丝桃苷、红景天苷、黄芪甲苷、槐果碱、川芎嗪、蝙蝠葛碱、白藜芦醇、丹参素)和中药复方及制剂(主要有益气活血方、稳心颗粒、复方黄芪养心合剂、复脉汤、乌头赤石脂丸方、养心定悸胶囊、枳实薤白桂枝汤、壮通饮、柴胡三参胶囊、参松养心胶囊)通过调控Cx43而改善GJ功能、减轻心肌缺血损伤的研究进展,以期为中医药新产品开发以及心肌缺血临床用药提供理论指导。
Myocardial ischemia is a common clinical disease.Traditional Chinese medicine has a clear effect on the prevention and treatment of myocardial ischemia injury,and its mechanism is a hot research topic.Connexion 43(Cx43)is a major component of gap junctions that mediate electrical coupling between adjacent cardiomyocytes.During myocardial ischemia,the abnormal distribution,expression and phosphorylation of Cx43 in cardiomyocytes may contribute to the development of myocardial ischemia by affecting gap junction function.This paper summarized the research progress of traditional Chinese medicine monomers and their active components(including sanguis draconis flavones,flavonoids in angelica sinensis,flavonoids in hypericum attenuatum choisy,ginkgetin,panax notoginseng saponins,hyperoside,salidroside,astragaloside IV,sophocarpine,ligustrazine,dauricine,resveratrol,danshensu),as well as traditional Chinese medicine compounds and preparations(including Yiqi Huoxue Prescription,Wenxin Granules,Compound Huangqi Yangxin Mixture,Fumai Decoction,Wutou Chishishhi Pill Formula,Yangxin Dingji Capsule,Zhishi Xiebai Guizhi Decoction,Zhuangtong Yin,Chaihu Sanshen Capsule,Shensong Yangxin Capsule),in improving gap junction function and alleviating myocardial ischemia injury by regulating Cx43,in order to provide theoretical guidance for the development of new traditional Chinese medicine products and clinical use of myocardial ischemia.
作者
王意程
黄欣桐
符挺
龚孜涵
王素琴
周露
WANG Yicheng;HUANG Xintong;FU Ting;GONG Zihan;WANG Suqin;ZHOU Lu(Kangda College of Nanjing Medical University,Lianyungang 222000,China)
出处
《药物评价研究》
CAS
北大核心
2024年第10期2434-2442,共9页
Drug Evaluation Research
基金
江苏省高等学校基础科学(自然科学)面上项目(21KJB310001,24KJD310003)
江苏省2023年大学生创新创业训练项目(202313980026Y)
连云港市重点研发计划基金项目(SF2249)。
关键词
中药单体
中药复方
心肌缺血
缝隙连接蛋白43
三七总皂苷
红景天苷
黄芪甲苷
稳心颗粒
参松养心胶囊
traditional Chinese medicine monomer
traditional Chinese medicine compound
myocardial ischemia
connexin 43
Panax notoginseng saponins
salidroside
astragaloside IV
Wenxin Granules
Shensong Yangxin Capsule
