摘要
男性低促性腺激素性性腺功能减退症(HH)是由促性腺激素(Gn)减退引起的一组以缺乏青春期发育、第二性征停止或退化、不育症为特征的疾病。激素替代治疗是该组疾病的主要治疗方法,可以促进患者第二性征的发育,合并小睾丸的HH患者的诱导生育是目前的治疗难题。治疗经验表明,仅应用睾酮类制剂、人绒毛膜促性腺激素(hCG)不能确保改善生育力,hCG联合人绝经期促性腺激素(hMG)注射和促性腺激素释放激素(GnRH)泵治疗可促进睾丸精子产生。新近研究表明,重组卵泡刺激素(rFSH)取得了某些积极效果。尤其对于严重的HH患者,rFSH的预处理以及序贯治疗方案提示更具有科学性和有效性。本综述将总结男性HH的治疗,重点阐述rFSH在该疾病中的应用,为改善男性生育力提供更多治疗选择。
Male hypogonadotropic hypogonadism(HH),caused by decreased gonadotropin(Gn),is a group of disorders characterized by lack of pubertal development,cessation or degeneration of secondary sex characteristics,and infertility.Hormone replacement therapy is the primary treatment for this disease and can promote the development of secondary sex characteristics in patients,but the induction of fertility in HH patients with microrchidia is a challenging problem currently.The application of testosterone-based preparations and human chorionic gonadotropin(hCG)alone is not sufficient to improve fertility,while combined treatment of hCG with human menopausal gonadotropin(hMG)injection and gonadotropin-releasing hormone(GnRH)pump can promote testicular sperm production.Recent studies have shown that recombinant follicle stimulating hormone(rFSH)has some positive effects.Especially for patients with severe HH,rFSH pretreatment and sequential treatment are more scientific and effective.This review summarizes the treatment of male HH,focusing on the application of rFSH in this disease,to provide more options for improving male fertility.
作者
柳彩虹
孙妍
Liu Caihong;Sun Yan(Department of Pediatrics,East Hospital,Affiliated Provincial Hospital of Shandong First Medical University,Jinan 250021,China)
出处
《中华实用儿科临床杂志》
CAS
CSCD
北大核心
2024年第11期874-877,共4页
Chinese Journal of Applied Clinical Pediatrics
