摘要
目的研究慢性阻塞性肺疾病(COPD)患者使用噻托溴铵吸入剂结合布地奈德福莫特罗治疗的效果,以及对血氧饱和度的影响。方法选取2021年3月-2023年3月在我院诊治的68例COPD患者为研究对象,采用随机数字表法分为对照组(n=34)和观察组(n=34),对照组采用噻托溴铵吸入剂治疗,观察组在对照组基础上给予布地奈德福莫特罗治疗,比较两组治疗效果、血气指标[动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))、血氧饱和度(SaO_(2))]、肺功能指标[第1秒用力呼气容积(FEV_(1))、用力肺活量(FVC)、第1秒用力呼气容积占预计值百分(FEV_(1)%)]、呼吸困难程度评分、不良反应发生率。结果观察组治疗总有效率为94.12%,高于对照组的82.35%(P<0.05);两组PaO_(2)、SaO_(2)均高于治疗前,PaCO_(2)低于治疗前,且观察组PaO_(2)、SaO_(2)高于对照组,PaCO_(2)低于对照组(P<0.05);两组FEV_(1)、FVC、FEV_(1)%均高于治疗前,且观察组高于对照组(P<0.05);两组MMRC评分均低于治疗前,且观察组低于对照组(P<0.05);观察组不良反应发生率为8.82%,与对照组的5.88%比较,差异无统计学意义(P>0.05)。结论噻托溴铵吸入剂结合布地奈德福莫特罗治疗COPD具有确切的效果,可提高治疗效果,改善肺功能、血氧饱和度,减轻呼吸困难,且不增加不良反应,是一种可行、有效、安全的治疗方案。
Objective To study the therapeutic effect of tiotropium bromide powder for inhalation combined with budesonide and formoterol fumarate in patients with chronic obstructive pulmonary disease(COPD)and its effect on blood oxygen saturation.Methods A total of 68 patients with COPD diagnosed and treated in our hospital from March 2021 to March 2023 were selected as the research objects.They were divided into control group(n=34)and observation group(n=34)by random number table method.The control group was treated with tiotropium bromide powder for inhalation,and the observation group was treated with budesonide and formoterol fumarate on the basis of the control group.The therapeutic effect,blood gas indexes[arterial partial pressure of oxygen(PaO_(2)),arterial partial pressure of carbon dioxide(PaCO_(2)),blood oxygen saturation(SaO_(2))],lung function indexes[forced expiratory volume in the first second(FEV_(1)),forced vital capacity(FVC),percentage of forced expiratory volume in the first second to predicted value(FEV_(1)%)],dyspnea score and incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 94.12%,which was higher than 82.35% in the control group(P<0.05).PaO_(2) and SaO_(2) in the two groups were higher than those before treatment,PaCO_(2) was lower than that before treatment,and PaO_(2) and SaO_(2) in the observation group were higher than those in the control group,PaCO_(2) was lower than that in the control group(P<0.05).The FEV_(1),FVC and FEV_(1)%of the two groups were higher than those before treatment,and those in the observation group were higher than those in the control group(P<0.05).The MMRC score of the two groups was lower than that before treatment,and that in the observation group was lower than that in the control group(P<0.05).The incidence of adverse reactions in the observation group was 8.82%,which was compared with 5.88% in the control group,the difference was not statistically significant(P>0.05).Conclu
作者
刘美玲
LIU Meiling(Department of Respiratory Medicine,Shangli County People's Hospital,Shangli 337009,Jiangxi,China)
出处
《医学信息》
2024年第21期138-141,共4页
Journal of Medical Information
关键词
COPD
噻托溴铵吸入剂
布地奈德福莫特罗
血氧饱和度
COPD
Tiotropium bromide powder for inhalation
Budesonide and formoterol fumarate
Blood oxygen saturation
