摘要
类风湿关节炎(rheumatoid arthritis,RA)是一种慢性、进行性、自身免疫性疾病,目前临床治疗RA的药物反应不足且伴有较严重的不良反应,因此寻找补充治疗药物很重要。黄芩苷是一种从黄芩根部分离出的黄酮类化合物,具有抗炎、抗氧化、抑制免疫反应等作用。研究表明,黄芩苷可抑制炎症介质释放,减轻炎症反应,减少氧自由基产生,降低氧化应激引起的滑膜损伤。通过NF-κB、MAPKS、JAK-STAT等途径,黄芩苷抑制炎症因子活化,诱导细胞凋亡,调节免疫细胞活性和免疫介质平衡,影响滑膜炎症的发生和发展。临床应用显示黄芩苷单药或参与复方制剂具有良好治疗效果和安全性,新型分子载药技术提高了其生物利用度,临床前景广阔。该文综述了黄芩苷在RA滑膜炎症机制及临床应用的研究进展。
Rheumatoid arthritis(RA)is a chronic and progressive autoimmune disease.Current clinical treatments for RA often exhibit inadequate drug responses and severe adverse effects,underscoring the necessity for alternative therapies.Baicalin,a flavonoid derived from Scutellaria baicalensis roots,possesses anti-inflammatory,antioxidant,and immunomodulatory properties.Research suggests that baicalin can inhibit the release of inflamma-tory mediators,thereby reducing inflammation.Moreover,it demonstrates antioxidant effects by decreasing reactive oxygen species production and mitigating synovial damage induced by oxidative stress.Baicalin may impede the activation of inflammatory cytokines through pathways such as NF-κB,MAPKs,and JAK-STAT signaling cascades while inducing apoptosis,regulating immune cell activity,and balancing immune mediators to impact synovitis progression.Clinically,both monotherapy with baicalin or its combination with other formulations have exhibited efficacy and safety profiles.The advancement in targeted drug delivery systems has improved its bioavailability further suggesting promising clinical applications.This review provides an overview of research progress on baicalin's mechanisms in inhibiting RA synovitis along with its clinical applications.
作者
沈小兰
刘小曼
侯晓强
黄惠莲
冯知涛
SHEN Xiaolan;LIU Xiaoman;HOU Xiaoqiang;HUANG Huilian;FENG Zhitao(College of Medicine and Health Sciences,China Three Gorges University,Yichang 443002,Hubei,China;The First Col-lege of Clinical Medical Sciences,China Three Gorges University,Yichang 443003,Hubei,China;不详)
出处
《实用医学杂志》
CAS
北大核心
2024年第22期3256-3261,共6页
The Journal of Practical Medicine
基金
国家自然科学基金项目(编号:81703783,82274333)。
关键词
类风湿关节炎
滑膜炎
抗氧化
黄芩苷
黄酮
rheumatoid arthritis
synovitis
anti-oxidation
baicalin
flavone
