摘要
目的探讨全身免疫炎症指数(SII)对类风湿关节炎(RA)的诊断价值。方法选取2021年1月至2022年12月该院收治的50例RA患者作为观察组,另选取同期该院50例健康体检者作为对照组。采用免疫比浊法检测两组血清类风湿因子(RF)、抗环瓜氨酸肽(CCP)抗体水平。收集白细胞计数(WBC)、中性粒细胞计数(N)、血小板计数(PLT)、淋巴细胞计数(L)、平均血小板体积(MPV)水平,计算SII(PLT×N/L)、PLR(PLT/L)、NLR(N/L)、PNR(PLT/N)和PWR(PLT/WBC)。比较两组各项指标的差异。采用Pearson相关分析血细胞相关指标与RF、抗CCP抗体的相关性。采用受试者工作特征(ROC)曲线分析SII对RA的诊断价值。结果观察组血清RF、抗CCP抗体水平及PLR、SII、NLR均高于对照组,L低于对照组,差异均有统计学意义(P<0.05);两组WBC、N、PLT、MPV、PNR及PWR比较,差异均无统计学意义(P>0.05)。SII与血清RF、抗CCP抗体水平均呈正相关(r=0.441、0.384,P<0.05),但相关性均较弱。ROC曲线分析结果显示,SII诊断RA的最佳截断值为0.26,曲线下面积为0.622,灵敏度为64.0%,特异度为62.0%。结论RA患者SII高于健康者,并且与RF、抗CCP抗体水平均呈正相关,动态监测其变化可为RA临床治疗方案的制订提供参考依据。
Objective To investigate the diagnostic value of systemic immune-inflammation index(SII)for rheumatoid arthritis(RA).Methods A total of 50 RA patients admitted to the hospital from January 2021 to December 2022 were selected as the observation group,and 50 healthy people in the hospital during the same period were selected as the control group.The levels of rheumatoid factor(RF)and anti-cyclic citrullinated peptide(CCP)antibody were detected by immunoturbidimetry.The levels of white blood cell count(WBC),neutrophil count(N),platelet count(PLT),lymphocyte count(L)and mean platelet volume(MPV)were collected,and SII(PLT×N/L),PLR(PLT/L),NLR(N/L),PNR(PLT/N)and PWR(PLT/WBC)were calculated.The differences of each index between the two groups were compared.Pearson correlation analysis was used to analyze the correlation between blood cell related indexes and RF,anti-CCP antibody.The receiver operating characteristic(ROC)curve was used to analyze the diagnostic value of SII for RA.Results The levels of serum RF,anti-CCP antibody,PLR,SII and NLR in the observation group were higher than those in the control group,and the L was lower than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in WBC,N,PLT,MPV,PNR and PWR between the two groups(P>0.05).SII was positively correlated with serum RF and anti-CCP antibody levels(r=0.441,0.384,P<0.05),but the correlations were weak.ROC curve analysis showed that the best cut-off value of SII for the diagnosis of RA was 0.26,the area under the curve was 0.622,the sensitivity was 64.0%,and the specificity was 62.0%.Conclusion SII in RA patients is higher than that in healthy people,and is positively correlated with RF and anti-CCP antibody levels.Dynamic monitoring of SII can provide a reference for the formulation of clinical treatment plans for RA.
作者
姚佳佳
YAO Jiajia(Department of Clinical Laboratory,Qinghai Provincial Hospital of Traditional Chinese Medicine,Xining,Qinghai 810000,China)
出处
《检验医学与临床》
CAS
2024年第22期3398-3401,共4页
Laboratory Medicine and Clinic
关键词
类风湿关节炎
全身免疫炎症指数
类风湿因子
抗环瓜氨酸肽抗体
相关性
rheumatoid arthritis
systemic immune inflammation index
rheumatoid factor
anti-cyclic citrullinated peptide antibody
relevance
