摘要
目的探讨精准营养治疗对慢性肝病合并营养不良患者免疫功能、肝功能及并发症的影响。方法选取2021年1月至2023年10月南昌大学第二附属医院收治的360例慢性肝病合并营养不良住院患者作为研究对象,采用随机数字表法分为对照组和干预组,每组180例。对照组采取常规营养干预,干预组采取精准营养治疗方案干预。比较两组人体测量学指标[体质量指数(BMI)、上臂围(MAC)和肱三头肌皮褶厚度(TSF)]、免疫功能(CD3^(+)、CD4^(+)、CD8^(+)和CD4^(+)/CD8^(+))、营养状况指标[血清总蛋白(STP)、清蛋白(ALB)和血红蛋白(Hb)]、肝功能指标[总胆红素(TBIL)和凝血酶原活动度(PTA)]水平及并发症发生情况。结果两组干预后BMI、MAC、TSF、CD3^(+)、CD4^(+)、PTA、STP、ALB、Hb水平及CD4^(+)/CD8^(+)均高于干预前,且干预组高于对照组(P<0.05);两组干预后CD8^(+)、TBIL水平均低于干预前,且干预组低于对照组(P<0.05)。干预组并发症发生率为11.11%,低于对照组的22.78%(P<0.05)。结论精准营养治疗用于慢性肝病合并营养不良患者能够有效改善其人体测量学、免疫功能、营养状况和肝功能指标,并且可降低并发症发生率。
Objective To investigate the effects of precision nutrition therapy on immune function,liver function and complications in patients with chronic liver disease and malnutrition.Methods A total of 360 hospitalized patients with chronic liver disease and malnutrition admitted to the Second Affiliated Hospital of Nanchang University from January 2021 to October 2023 were selected as the research objects.They were divided into control group and intervention group by random number table method,with 180 cases in each group.The control group received routine nutritional intervention,and the intervention group received precision nutritional treatment.Anthropometric indicators[body mass index(BMI),upper arm circumference(MAC)and triceps skinfold thickness(TSF)],immune function(CD3^(+),CD4^(+),CD8^(+)and CD4^(+)/CD8^(+)),nutritional status indicators[serum total protein(STP),albumin(ALB)and hemoglobin(Hb)],and liver function indicators[Total bilirubin(TBIL)and prothrombin activity(PTA)]levels and complications were compared between the two groups.Results After intervention,the levels of BMI,MAC,TSF,CD3^(+),CD4^(+),PTA,STP,ALB,Hb and CD4^(+)/CD8^(+)in the two groups were higher than those before intervention,and those in the intervention group were higher than those in the control group(P<0.05).The levels of CD8^(+)and TBIL in the two groups after intervention were lower than those before intervention,and those in the intervention group were lower than those in the control group(P<0.05).The incidence of complications in the intervention group(11.11%)was lower than that in the control group(22.78%)(P<0.05).Conclusion Precision nutrition therapy for patients with liver disease and malnutrition can improve effectively the anthropometry,immune function,nutritional status and chronic liver function indexes,and which can reduce the incidence of complications.
作者
胡奕婷
喻蓉艳
张芳
占倩倩
康飞飞
胡应骏
HU Yiting;YU Rongyan;ZHANG Fang;ZHAN Qianqian;KANG Feifei;HU Yingjun(Department of Infectious Diseases,the Second Affiliated Hospital of Nanchang University,Nanchang,Jiangxi 330000,China;Department of Pharmacy,the First Affiliated Hospital of Nanchang University,Nanchang,Jiangxi 330000,China)
出处
《检验医学与临床》
CAS
2024年第22期3388-3392,共5页
Laboratory Medicine and Clinic
基金
江西省卫生健康委员会科技计划项目(202210511)。
关键词
精准营养治疗
慢性肝病
营养不良
免疫功能
并发症
precision nutrition therapy
chronic liver disease
malnutrition
immune function
complication
