摘要
目的分析联合用药方案“司美格鲁肽+依折麦布片”在2型糖尿病合并冠状动脉粥样硬化性心脏病(简称冠心病)心绞痛患者中的实际治疗效果。方法选取2022年1—12月揭西县人民医院收治的100例2型糖尿病合并冠心病心绞痛患者作为研究对象,根据不同治疗方法分为两组,每组50例,对照组采用常规治疗+依折麦布片治疗,研究组在对照组基础上加用司美格鲁肽。对比两组血糖指标、明尼苏达心功能不全生命质量量表评分、心绞痛发作频率及不良反应发生率。结果治疗后,两组空腹血糖、餐后2 h血糖、明尼苏达心功能不全生命质量量表评分、心绞痛发作频率均低于治疗前,且研究组均低于对照组,差异有统计学意义(P均<0.05)。两组不良反应发生率对比,差异无统计学意义(P>0.05)。结论2型糖尿病合并冠心病心绞痛患者应用司美格鲁肽+依折麦布片联合治疗,可提升血糖控制效果,改善心功能,且用药安全性较高。
Objective To analyze the actual therapeutic effect of the combination regimen smeglutide+ezetimibe tab⁃lets in patients with type 2 diabetes mellitus complicated with coronary atherosclerotic heart disease(referred to as coronary heart disease)angina pectoris.Methods A total of 100 patients with type 2 diabetes mellitus complicated with coronary heart disease and angina pectoris admitted to Jiexi People's Hospital from January to December 2022 were selected as the research objects.According to different treatment methods,they were divided into two groups,with 50 cases in each group.The control group was treated with conventional treatment+ezetimibe tablets,and the study group was treated with semeglutide on the basis of the control group.The blood glucose index,Minnesota Heart Insufficiency Quality of Life Scale score,angina pectoris attack frequency and incidence of adverse reactions were compared between the two groups.Results After treatment,the fasting blood glucose,2-hour postprandial blood glu⁃cose,Minnesota cardiac insufficiency quality of life scale score and angina pectoris attack frequency in the two groups were lower than those before treatment,and those in the study group were lower than the control group,the differences were statistically significant(all P<0.05).There was no significant difference in the incidence of adverse reactions be⁃tween the two groups(P>0.05).Conclusion Patients with type 2 diabetes mellitus complicated with coronary heart dis⁃ease and angina pectoris were treated with smeglutide+ezetimibe tablets,which could improve the effect of blood glu⁃cose control and improve cardiac function,and the drug safety was high.
作者
蔡芳芳
张优创
张燕妮
张瑞萍
CAI Fangfang;ZHANG Youchuang;ZHANG Yanni;ZHANG Ruiping(Department of Internal Medicine IV,Jiexi People's Hospital,Jieyang 515400,Guangdong,China)
出处
《糖尿病新世界》
2024年第15期109-112,共4页
Diabetes New World
关键词
2型糖尿病
冠心病心绞痛
司美格鲁肽注射液
依折麦布片
不良反应
Type 2 diabetes mellitus
Coronary heart disease and angina pectoris
Semaglutide injection
Ezetimibe tablets
Adverse reactions
