摘要
目的探讨血清β2微球蛋白(β2-microglobulin,β2-MG)与尿微量白蛋白(microalbuminuria,mALB)对于糖尿病肾病(diabetic nephropathy,DN)的诊断效能。方法选取2023年6月—2024年3月菏泽市第六人民医院收治的120例疑似DN患者,所有患者均接受血清β2-MG、mALB检验。以肾穿刺活检结果为金标准,比较血清β2-MG、mALB单项检验与联合检验对DN的诊断效能以及对不同DN分期的诊断符合率。结果经肾穿刺活检确诊DN58例,单纯2型糖尿病62例,其中血清β2-MG检验阳性59例,mALB检验阳性61例,血清β2-MG联合mALB检验阳性59例。血清β2-MG联合mALB诊断DN的特异度、灵敏度、准确度均高于单项血清β2-MG、mALB检验,差异有统计学意义(P均<0.05)。血清β2-MG联合mALB诊断Ⅲ期DN的符合率高于单项血清β2-MG、mALB检验,差异有统计学意义(P<0.05)。血清β2-MG联合mALB诊断Ⅰ期、Ⅱ期、Ⅳ期、Ⅴ期DN的符合率与单项血清β2-MG、mALB检验对比,差异无统计学意义(P均>0.05)。结论血清β2-MG与mALB对于DN具有较高的诊断效能,特别是对Ⅲ期DN的诊断符合率更高,为临床后续诊疗提供了重要的参考信息。
Objective To investigate the diagnostic efficacy of serumβ2-microglobulin(β2-MG)and microalbumin⁃uria(mALB)in diabetic nephropathy(DN).Methods A total of 120 patients with suspected DN admitted to Heze Sixth People's Hospital from June 2023 to March 2024 were selected.All patients received serumβ2-MG and mALB tests.The results of renal biopsy were used as the gold standard to compare the diagnostic efficacy of serumβ2-MG and mALB single index text and combined test for DN,as well as the diagnostic coincidence rate for different DN stages.Results There were 58 cases of DN and 62 cases of simple type 2 diabetes mellitus were diagnosed by renal bi⁃opsy,including 59 cases of positive serumβ2-MG test,61 cases of positive mALB test,and 59 cases of positive se⁃rumβ2-MG combined with mALB test.The specificity,sensitivity and accuracy of serumβ2-MG combined with mALB in the diagnosis of DN were higher than those of single serumβ2-MG and mALB,and the differences were sta⁃tistically significant(all P<0.05).The coincidence rate of serumβ2-MG combined with mALB in the diagnosis of stage III DN was higher than that of single serumβ2-MG and mALB,and the difference was statistically significant(P<0.05).There were no significant differences in the coincidence rate of serumβ2-MG combined with mALB in the di⁃agnosis of stageⅠ,Ⅱ,ⅣandⅤDN compared with single serumβ2-MG and mALB(all P>0.05).Conclusion Se⁃rumβ2-MG and mALB have a high diagnostic efficiency for DN,especially the diagnostic coincidence rate of stageⅢDN is higher,which provides important reference information for clinical follow-up diagnosis and treatment.
作者
葛妍妍
GE Yanyan(Department of Laboratory,Heze Sixth People's Hospital,Heze 274000,Shandong,China)
出处
《糖尿病新世界》
2024年第15期56-58,62,共4页
Diabetes New World
