摘要
近年来,阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的发病率不断增高,其合并慢性肾脏病(CKD)的临床病例报道也日益增多。越来越多的研究表明,OSAHS和CKD相互影响,OSAHS通过慢性间歇性缺氧、氧化应激、激活肾素-血管紧张素-醛固酮系统活性及升高血压引起和加重CKD;CKD通过液体超载、化学反射敏感性改变和尿毒症引起神经病变等机制促进OSAHS的发生发展。本文系统综述了OSAHS和CKD的流行病学特点,从病理生理学角度阐明了两者间相互影响的研究现状,以期为后续研究提供新思路。
The prevalence of obstructive sleep apnea hypopnea syndrome(OSAHS)has been increasing in recent years,and there have been an increasing number of clinical case reports of OSAHS associated with chronic kidney disease(CKD).More and more studies have shown that OSAHS and CKD influence each other.OSAHS can induce CKD through chronic intermittent hypoxia,oxidative stress,activation of renin-angiotensin-aldosterone system activity,and elevated blood pressure;and CKD can also contribute to the development of OSAHS through fluid overload,altered chemoreflex sensitivity,and uremia-induced neuropathy.This article systematically reviews the epidemiologic characteristics of OSAHS and CKD and elucidates the current state of research on the relationship between the two from a pathophysiologic point of view,with the goal of providing new ideas for subsequent research.
作者
李亚男(综述)
乔晞(审校)
LI Yanan;QIAO Xi(Department of Nephrology,Second Hospital of Shanxi Medical University,Shanxi Kidney Disease Institute,Kidney Research Center of Shanxi Medical University,Taiyuan 030001,China)
出处
《肾脏病与透析肾移植杂志》
CAS
CSCD
2024年第5期469-473,共5页
Chinese Journal of Nephrology,Dialysis & Transplantation
