摘要
目的探讨补充性肠外营养联合肠内营养对慢性阻塞性肺疾病(COPD)稳定期呼吸康复患者肺功能、临床症状及生活质量的影响。方法选择80例COPD稳定期患者,按照随机数字表法分为两组,研究组(n=40)和对照组(n=40)。所有患者均进行呼吸康复训练,对照组给予肠内营养,研究组给予补充性肠外营养联合肠内营养。比较两组患者治疗前后的肺功能、临床症状、营养指标、免疫功能及COPD评估测试(CAT)量表的差异。结果治疗后,研究组用力肺活量(FVC)、一秒用力呼气容积(FEV1)、FEV1/FVC水平高于对照组,差异均有统计学意义(t分别=8.42、12.95、12.50,P均<0.05);研究组慢性咳嗽、咳痰、气短及呼吸困难评分均低于对照组,差异均有统计学意义(t分别=3.01、2.24、4.23、6.51,P均<0.05);研究组总蛋白、白蛋白、血红蛋白水平均高于对照组,差异均有统计学意义(t分别=3.59、5.52、3.44,P均<0.05);研究组免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、淋巴细胞水平均高于对照组,差异均有统计学意义(t分别=3.51、4.38、2.74,P均<0.05);研究组CAT总分均低于对照组,差异有统计学意义(t=-2.20,P<0.05)。结论呼吸康复基础上给予补充性肠外营养联合肠内营养可显著增强COPD稳定期患者肺功能,改善临床症状,并可通过改善营养状态及免疫功能而提高生活质量。
Objective To investigate the effects of supplemental parenteral nutrition combined with enteral nutrition on pulmonary function,clinical symptoms,and quality of life in patients with the stable phase of COPD during respiratory rehabilitation.Methods Eighty patients with stable COPD were divided into two groups according to random number ta⁃ble method:study group(n=40)and control group(n=40).All patients received respiratory rehabilitation training,with the control group receiving enteral nutrition and the study group receiving supplemental parenteral nutrition combined with enteral nutrition.The differences of pulmonary function,clinical symptoms,nutritional indicators,immune function,and COPD assessment test(CAT)scale before and after treatment were compared between the two groups.Results Af⁃ter treatment,the levels of forced vital capacity(FVC),forced expiratory volume in one second(FEV1),FEV1/FVC in study group were higher than those in control group(t=8.42,12.95,12.50,P<0.05).The scores of chronic cough,expec⁃toration,shortness of breath and dyspnea in the study group were lower than those in the control group(t=3.01,2.24,4.23,6.51,P<0.05).The levels of total protein,albumin and hemoglobin in the study group were higher than those in the control group(t=3.59,5.52,3.44,P<0.05).The levels of IgA,IgG and lymphocytes in the study group were higher than those in the control group(t=3.51,4.38,2.74,P<0.05).The total CAT score of the study group was lower than that of the control group(t=-2.20,P<0.05).Conclusion On the basis of re⁃spiratory rehabilitation,supplementary parenteral nutrition combined with enteral nutrition can sig⁃nificantly enhance pulmonary function,improve clinical symptoms,and improve quality of life by improving nutritional status and immune function in stable COPD patients.
作者
刘仙莲
朱建生
徐瑶
蔡利苹
LIU Xianlian;ZHU Jiansheng;XU Yao(Department of Nutrition,Jiangshan People's Hospital,Quzhou 324100,China)
出处
《全科医学临床与教育》
2024年第11期974-977,共4页
Clinical Education of General Practice
基金
浙江省医学会临床医学科研专项资金项目(2022ZYC-B26)。
关键词
慢性阻塞性肺疾病
呼吸康复
补充性肠外营养
肠内营养
免疫
chronic obstructive pulmonary disease
respiratory rehabilitation
supplemental parenteral nutrition
enteral nutrition
immune
