摘要
目的:分析无创正压通气联合雾化吸入治疗慢性阻塞性肺疾病急性加重期合并呼吸衰竭(AECOPD)的效果。方法:选取成都市新都区第三人民医院急诊科2022年1月—2023年4月收治的60例AECOPD合并呼吸衰竭患者,随机分为对照组和观察组,各30例。在常规治疗基础上,对照组行常规急诊治疗和无创正压通气治疗,观察组在对照组基础上给予雾化吸入治疗。比较两组临床疗效、恢复指标、血气指标、生命体征及不良反应发生情况。结果:观察组治疗总有效率高于对照组(P=0.011);观察组呼吸困难缓解时间、通气时间和住院时间短于对照组,日均排痰量多于对照组(P<0.05);治疗后,两组动脉血二氧化碳分压、呼吸频率、心率降低,动脉血氧分压、酸碱值水平升高,观察组动脉血二氧化碳分压、动脉血氧分压、呼吸频率、心率优于对照组(P<0.05);两组不良反应发生率比较,差异无统计学意义(P=0.667)。结论:无创正压通气联合雾化吸入治疗AECOPD伴呼吸衰竭的效果较好,可以改善患者的呼吸状态和血气指标,维持生命体征稳定,具有较高的安全性。
Objective:To analyze the effect of noninvasive positive pressure ventilation combined with atomized inhalation on acute exacerbation of chronic obstructive pulmonary disease with respiratory failure(AECOPD).Methods:Sixty patients with AECOPD combined with respiratory failure admitted to Department of Emergency,Chengdu Xindu District Third People's Hospital from January 2022 to April 2023 were randomly divided into control group and observation group,with thirty cases in each group.On the basis of conventional treatment,the control group received routine emergency treatment and noninvasive positive pressure ventilation treatment,and the observation group received atomized inhalation treatment on the basis of the control group.The clinical efficacy,recovery indexes,blood gas indexes,vital signs and the occurrence of adverse reactions were compared between the two groups.Results:The total effective rate of observation group was higher than that of control group(P=0.011);the dyspnea relief time,ventilation time and hospital stay in the observation group were shorter than those in the control group,and the average daily sputum output was higher than that in the control group(P<0.05);after treatment,the levels of arterial partial pressure of carbon dioxide,respiratory rate and heart rate decreased,while the levels of arterial partial pressure of oxygen and pH increased in the two groups,the levels of arterial partial pressure of carbon dioxide,arterial partial pressure of oxygen,respiratory rate and heart rate in the observation group were better than those in the control group(P<0.05);there was no significant difference in the incidence of adverse reactions between the two groups(P=0.667).Conclusion:Noninvasive positive pressure ventilation combined with atomized inhalation has a good effect on the treatment of AECOPD with respiratory failure,which can improve the respiratory status and blood gas indexes of patients,maintain stable vital signs,and have a high safety.
作者
赵鹏
唐凤华
陈小建
Zhao Peng;Tang Fenghua;Chen Xiaojian(Department of Emergency,Chengdu Xindu District Third People's Hospital,Chengdu 610000,Sichuan Province,China)
出处
《中外医药研究》
2024年第28期30-32,共3页
JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH
关键词
慢性阻塞性肺疾病急性加重期
呼吸衰竭
无创正压通气
雾化吸入
Acute exacerbation of chronic obstructive pulmonary disease
Respiratory failure
Noninvasive positive pressure ventilation
Atomized inhalation
