摘要
目的探讨中医综合治疗方案对难治性鼻窦炎患者的临床疗效。方法164例患者随机分为对照组和观察组,每组82例,对照组给予西医综合治疗方案(生理性海水鼻腔喷雾器、布地奈德鼻喷雾剂、克拉霉素片),观察组给予中医综合治疗方案(辛芷通窍颗粒、辛白熏鼻散、蝶腭神经节针刺),疗程3个月。检测临床疗效、主观病情指标(临床症状评分、SNOT-20评分、肺经蕴热证评分)、客观病情指标(Lund-Kennedy评分、T&T嗅觉评分、MTT、MTR)、炎症指标(LTC4、IL-17a、IL-33、ECP)、免疫指标(CD4^(+)、CD8^(+)、Treg、Th17、CD4^(+)/CD8^(+)、Th17/Treg)、安全性指标变化。结果观察组总控制率高于对照组(P<0.05)。治疗后和随访3个月,2组临床症状评分、炎症因子、CD8^(+)、Th17、Th17/Treg、SNOT-20评分、肺经蕴热证评分、Lund-Kennedy评分、T&T嗅觉评分降低(P<0.05),CD4^(+)、Treg、CD4^(+)/CD8^(+)、MTR升高(P<0.05),MTT缩短(P<0.05),以观察组更明显(P<0.05)。2组未发现严重不良反应。结论中医综合治疗方案可安全有效地改善难治性鼻窦炎患者炎症反应、免疫功能和黏液纤毛运动功能,修复鼻黏膜形态和功能,缓解主客观症状,提高生活质量。
AIM To explore the clinical effects of comprehensive treatment regimen of traditional Chinese medicine on patients with refractory rhinosinusitis.METHODS One hundred and sixty-four patients were randomly assigned into control group(82 cases)for 3-month intervention of comprehensive treatment regimen of western medicine(Physiological Seawater Nasal Spray,Budesonide Nasal Spray,Clarithromycin Tablets),and observation group(82 cases)for 3-month intervention of comprehensive treatment regimen of traditional Chinese medicine(Xinzhi Tongqiao Granules,Xinbai Nasal Fumigation Powder,acupuncture of sphenopalatine ganglion).The changes in clinical effects,subjective disease indices(clinical symptom scores,SNOT-20 score,Lung Meridian Heat Accumulation Syndrome score),objective disease indices(Lund-Kennedy score,T&T olfactory score,MTT,MTR),inflammatory indices(LTC4,IL-17a,IL-33,ECP),immune indices(CD4^(+),CD8^(+),Treg,Th17,CD4^(+)/CD8^(+),Th17/Treg)and safety indices were detected.RESULTS The observation group demonstrated higher total control rate than the control group(P<0.05).After the treatment and at 3-month follow-up,the two groups displayed decreased clinical symptom scores,inflammatory indices,CD8^(+),Th17,Th17/Treg,SNOT-20 score,Lung Meridian Heat Accumulation Syndrome score,Lund-Kennedy score,T&T olfactory score(P<0.05),increased CD4^(+),Treg,CD4^(+)/CD8^(+),MTR(P<0.05),and shortened MTT(P<0.05),especially for the observation group(P<0.05).No obvious adverse reactions were observable in the two groups.CONCLUSION For the patients with refractory rhinosinusitis,the comprehensive treatment regimen of traditional Chinese medicine can safely and effectively improve inflammatory responses,immune functions and mucociliary motor functions,repair the status and functions of nasal mucosa,alleviate subjective and objective symptoms,and enhance life quality.
作者
李群真
李军
苗忠义
范少希
燕茹
马凤梅
荣婷
LI Qun-zhen;LI Jun;MIAO Zhong-yi;FAN Shao-xi;YAN Ru;MA Feng-mei;RONG Ting(Hebei Provincial Hospital of Traditional Chinese Medicine,Shijiazhuang 050011,China)
出处
《中成药》
CAS
CSCD
北大核心
2024年第11期3645-3650,共6页
Chinese Traditional Patent Medicine
基金
河北省中医药管理局科研计划项目(2023028)。
关键词
辛芷通窍颗粒
辛白熏鼻散
蝶腭神经节
难治性鼻窦炎
Xinzhi Tongqiao Granules
Xinbai Nasal Fumigation Powder
sphenopalatine ganglion
refractory sinusitis
