摘要
目的 探讨含兰索拉唑的四联方案治疗老年慢性萎缩性胃炎的效果及对患者胃功能的影响。方法 选取2021年1月—2023年12月收治的108例老年幽门螺杆菌(Hp)阳性慢性萎缩性胃炎患者为研究对象,按照随机数字表法分为观察组和对照组,各54例。对照组采用常规四联疗法(奥美拉唑+阿莫西林+克拉霉素+胶体果胶铋)治疗,观察组采用含兰索拉唑四联方案(兰索拉唑+阿莫西林+克拉霉素+胶体果胶铋)治疗,比较两组临床疗效、Hp根除率、胃功能指标[胃蛋白酶原(PG)Ⅰ、PGⅡ、胃泌素(G)-17]、胃黏膜恢复指标[表皮生长因子(EGF)、一氧化氮(NO)]、炎症指标[白细胞介素(IL)-6、IL-12、肿瘤坏死因子(TNF)-α]和不良反应。结果 治疗后,观察组总有效率和Hp根除率均高于对照组(P<0.05),外周血PGⅠ、PGⅡ、G-17、EGF、NO水平均高于对照组(P<0.05),IL-6、IL-12、TNF-α水平均低于对照组(P<0.05),两组不良反应总发生率比较差异无统计学意义(P>0.05)。结论 含兰索拉唑的四联方案治疗老年Hp阳性慢性萎缩性胃炎患者的效果显著,可有效加快胃黏膜恢复,提高胃功能,降低炎症反应。
Objective To explore the effect of quadruple regimen with Lansoprazole in elderly patients with chronic atrophic gastritis and its influence on gastric function.Methods A total of 82 elderly patients with Helicobacter pylori(Hp)-positive chronic atrophic gastritis were enrolled as the research objects between January 2021 and December 2023.They were randomly divided into an observation group and a control group according to random number table,54 cases in each group.The control group was treated with routine quadruple therapy(Omeprazole+Amoxicillin+Clarithromycin+Colloidal Bismuth Pectin),while the observation group was treated with quadruple regimen containing Lansoprazole(Lansoprazole+Amoxicillin+Clarithromycin+Colloidal Bismuth Pectin).The clinical curative effect,Hp eradication rate,gastric function indexes[pepsinogen(PG-)Ⅰ,PG-Ⅱ,and gastrin(G)-17],gastric mucosal recovery indexes[epidermal growth factor(EGF),nitric oxide(NO)],inflammatory indexes[interleukin(IL)-6,IL-12,tumor necrosis factor(TNF)-α]and adverse reactions were compared between the two groups.Results The total effective rate and Hp eradication rate in the observation group were higher than those in the control group(P<0.05).After treatment,levels of peripheral blood PG-Ⅰ,PG-Ⅱ,G-17,EGF and NO in observation group were higher than those in control group(P<0.05),and levels of IL-6,IL-12 and TNF-αwere lower than those in control group(P<0.05).There was no significant difference in total incidence on adverse reactions between the two groups(P>0.05).Conclusion The curative effect of quadruple regimen with Lansoprazole is significant in elderly patients with Hp-positive chronic atrophic gastritis,which can effectively accelerate the recovery of gastric mucosa,improve gastric function and reduce inflammatory response.
作者
张汪来
邵璜
陶运生
李猛
周泽林
吴福宁
Zhang Wanglai;Shao Huang;Tao Yunsheng;Li Meng;Zhou Zelin;Wu Funing(Department of Hepatology,Spleen and Stomach Disease,Tongling Traditional Chinese Medicine Hospital,Tongling 244000;Department of Ultrasound Room,Tongling Traditional Chinese Medicine Hospital,Tongling 244000)
出处
《国际老年医学杂志》
2024年第6期712-716,共5页
International Journal of Geriatrics
基金
全国名老中医药专家传承工作室建设项目(国中医药人教函[2022]75号)
铜陵市卫生健康委医学科研项目(卫科研[2021]24号)。
关键词
慢性萎缩性胃炎
兰索拉唑
幽门螺杆菌
Chronic atrophic gastritis
Lansoprazole
Helicobacter pylori
