摘要
目的探究幽门螺旋杆菌阳性慢性浅表性胃炎患者应用益生菌联合铋剂四联治疗的效果。方法将福建省福清市医院自2021年2月至2023年10月收治的120例HP阳性慢性浅表性胃炎患者纳入研究。采用完全随机分组法均分为试验组及对照组,每组均为60例。对照组采用铋剂四联治疗,试验组加用益生菌治疗。比较两组的治疗效果、HP转阴率、临床症状改善情况、胃肠功能水平、炎性因子水平及安全性。结果试验组治疗效果高于对照组(P<0.05);试验组HP转阴率高于对照组(P<0.05);试验组临床症状改善情况中腹胀、恶心呕吐、反酸嗳气及上腹痛症状消失时间均少于对照组(P<0.05);试验组胃肠功能中PGⅠ、PGⅡ水平均低于对照组(P<0.05);试验组胃肠功能中GAS水平高于对照组(P<0.05);试验组不良反应率低于对照组(P<0.05)。结论对比单独应用铋剂四联治疗,益生菌联合治疗能够提高HP阳性慢性浅表性胃炎患者的疗效,改善临床症状及胃肠功能,降低炎性因子水平,且不良反应较少,安全性较好。
Objective To investigate the effect of probiotics combined with bismuth quadruple therapy on patients with Helicobacter pylori positive chronic superficial gastritis.Methods A total of 120 patients with HP positive chronic superficial gastritis admitted to Fuqing Hospital in Fujian Province from February 2021 to October 2023 were included in the study.Using the complete random grouping method,the participants were evenly divided into an experimental group and a reference group,with 60 cases in each group.The reference group was treated with bismuth quadruple therapy,while the experimental group was treated with probiotics.Compare the treatment efficacy,HP conversion rate,clinical symptom improvement,gastrointestinal function level,inflammatory factor level,and safety between the two groups.Results The treatment effect of the experimental group was higher than that of the reference group(P<0.05);the negative conversion rate of HP in the experimental group was higher than that in the reference group(P<0.05);the disappearance time of abdominal distension,nausea and vomiting,acid reflux and belching,and upper abdominal pain symptoms in the improvement of clinical symptoms in the experimental group was less than that in the reference group(P<0.05);the levels of PGⅠand PGⅡin the gastrointestinal function of the experimental group were lower than those in the reference group(P<0.05);the level of GAS in the gastrointestinal function of the experimental group was higher than that in the reference group(P<0.05);the adverse reaction rate of the experimental group was lower than that of the reference group(P<0.05).Conclusions Compared to the application of bismuth quadruple therapy alone,the combination of probiotics can improve the therapeutic effect in patients with HP-positive chronic superficial gastritis,alleviate clinical symptoms and gastrointestinal function,reduce the levels of inflammatory factors,and have fewer adverse reactions,with better safety.
作者
王命兴
陈秀清
WANG Mingxing;CHEN Xiuqing(Department of Gastroenterology,Fuqing City Hospital,Fuzhou 350300,China;Department of Health Care,Fuqing City Hospital in Fujian Province,Fuzhou 350300,China)
出处
《中国医药指南》
2024年第32期67-69,共3页
Guide of China Medicine
关键词
慢性浅表性胃炎
HP阳性
益生菌
铋剂四联
治疗效果
HP转阴率
Chronic superficial gastritis
HP positive
Probiotics
Bismuth agent quadruple
Therapeutic effect
HP conversion rate