摘要
目的探究系统性红斑狼疮(systemic lupus erythematosus,SLE)患儿血脂代谢指标特征和危险因素。方法选取成都市妇女儿童中心医院2013年1月至2022年8月住院并确诊为SLE的患儿54例,收集患儿临床资料,检测所有患儿血脂代谢指标和生化指标,采用二元logistic回归分析SLE患儿预后危险因素。结果入院时出现血脂代谢异常的SLE患儿共47例(87.04%),主要表现为LDL-C、TG和TC水平升高,HDL-C水平降低,预后良好组心血管系统损害、血液系统损害、尿蛋白阳性占比及SLEDAI-2000评分均低于预后不良组,dsDNA阳性占比高于预后不良组,二元logistic回归分析表明心血管系统损害、尿蛋白阳性为预后不良的危险因素,差异有统计学意义(P<0.05)。结论血脂代谢异常在SLE患儿中较常见,心血管系统损害、尿蛋白阳性可能增加患儿预后不良风险。
Objective To explore the characteristics of blood lipid metabolism indicators and risk factors of prognosis in children with systemic lupus erythematosus(SLE).Methods A total of 54 children who were diagnosed with SLE and hospitalized in Chengdu Women and Children′s Central Hospital from January 2013 to August 2022 were selected.Clinical data of all children were collected and blood lipid metabolism indicators and biochemical indicators were detected,and binary logistic regression was used to analyze the prognosis risk factors in children with SLE.Results Among the 47 cases(87.04%)had abnormal blood lipid metabolism at admission,and is mainly manifested as elevated levels of LDL-C,TG and TC and decreased level of HDL-C.The proportion of cardiovascular system damage,hematological system damage,urinary protein positivity,and SLEDAI-2000 score in the group with good prognosis were lower than those in the group with poor prognosis,while the proportion of dsDNA positivity was higher in the group with poor prognosis.Binary Logistic regression analysis showed that the cardiovascular system damage and positive urinary protein were risk factors for poor prognosis,with statistically significant differences(P<0.05).Conclusion Abnormal blood lipid metabolism is common in children with SLE,and cardiovascular system damage and positive urinary protein may increase the risk of poor prognosis in young children.
作者
程芹
魏心怡
张伟
李莎
李经纬
彭媛媛
方钰
谢雪
CHENG Qin;WEI Xinyi;ZHANG Wei;LI Sha;LI Jingwei;PENG Yuanyuan;FANG Yu;XIE Xue(Department of Pediatric Rheumatology and Immunology,Chengdu Women′s and Children′s Central Hospital,School of Medicine,University of Electronic Science and Technology of China,Chengdu,Sichuan 611731,China)
出处
《公共卫生与预防医学》
2024年第6期157-160,共4页
Journal of Public Health and Preventive Medicine
关键词
儿童
系统性红斑狼疮
血脂代谢
Children
Systemic lupus erythematosus
Blood lipid metabolism
