摘要
目的:探析达肝素钠抗凝在血吸虫病肝硬化合并门静脉血栓中的应用效果。方法:选取2021年5月—2023年5月荆州市第三人民医院收治的80例血吸虫病肝硬化合并门静脉血栓患者作为研究对象,按照随机数表法将患者分为对照组与观察组,各40例。对照组给予抗炎、保肝等常规治疗,观察组加用达肝素钠抗凝治疗。比较两组门静脉血栓体积[于治疗前(T_(1))、治疗1个月(T_(2))、治疗3个月(T_(3))及治疗6个月(T4)测定]、凝血指标(凝血酶原时间、血小板计数)、肝功能指标[丙氨酸氨基转移酶(alanine transaminase,ALT)、天冬氨酸氨基转移酶(aspartate transferase,AST)、血清白蛋白(serum albumin,ALB)]及并发症。结果:T_(2)、T_(3)、T_(4),两组门静脉血栓体积较T1缩小,凝血酶原时间延长,血小板计数升高,且观察组门静脉血栓体积小于对照组,凝血酶原时间长于对照组,血小板计数高于对照组,组间、时点、组间与时点交互比较,差异有统计学意义(P<0.05)。治疗6个月,两组ALT、AST低于治疗前,ALB高于治疗前,且观察组优于对照组,差异有统计学意义(P<0.05)。观察组并发症发生率低于对照组,门静脉血管再通率高于对照组,差异有统计学意义(P<0.05)。结论:达肝素钠抗凝可有效改善血吸虫病肝硬化合并门静脉血栓患者的血栓体积,改善凝血及肝功能指标,还可降低并发症发生率,促进血管再通。
Objective:To explore the application effect of Dalteparin Sodium anticoagulation in schistosomiasis cirrhosis complicated with portal vein thrombosis.Method:A total of 80 patients with schistosomiasis cirrhosis complicated with portal vein thrombosis who admitted to Jingzhou Third People's Hospital from May 2021 to May 2023 were selected as the research objects,the patients were divided into control group and observation group according to the random number table method,with 40 cases in each group.The control group was given routine treatment such as anti-inflammatory and liver protection,and the observation group was treated with Dalteparin Sodium anticoagulation.The portal vein thrombosis volume[measured before treatment(T_(1)),1 month after treatment(T_(2)),3 months after treatment(T_(3))and 6 months after treatment(T_(4))],coagulation indexes(prothrombin time,platelet count),liver function indexes[alanine transaminase(ALT),aspartate transferase(AST),serum albumin(ALB)]and complications were compared between two groups.Result:Compared with T_(2),T_(3)and T_(4),the portal vein thrombosis volume in two groups at T1 were reduced,the prothrombin times were prolonged,and the platelet count were increased,the portal vein thrombosis volume in the observation group was smaller than that in the control group,the prothrombin time was longer than that in the control group,and the platelet count was higher than that in the control group,there were statistically significant differences between groups,time points,and interaction between groups and time points(P<0.05).At 6 months of treatment,the ALT and AST in two groups were lower than those before treatment,ALB were higher than those before treatment,and those in the observation group were better than those in the control group,the differences were statistically significant(P<0.05).The incidence of complications in the observation group was lower than that in the control group,and the recanalization rate of portal vein thrombosis was higher than that in the control group,
作者
田岳霄
胡恒
宁娟
TIAN Yuexiao;HU Heng;NING Juan(Jingzhou Third People's Hospital,Jingzhou 434000,China;不详)
出处
《中外医学研究》
2024年第31期5-8,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
达肝素钠
血吸虫病
肝硬化
门静脉血栓
并发症
Dalteparin Sodium
Schistosomiasis
Cirrhosis
Portal vein thrombosis
Complications
