摘要
戊型肝炎病毒(hepatitis E virus,HEV)是导致急性病毒性肝炎常见的病原体,抗-HEV免疫球蛋白M(immunoglobulin M,IgM)是重要的诊断指标之一。本文报道3例基因4型HEV感染者,患者在入院时初始抗-HEV IgM均为阴性,住院期间复查阳转,抗-HEV IgM阳转时伴抗-HEV免疫球蛋白G(immunoglobulin G,IgG)阳转或水平升高。3例HEV感染者的临床数据提示,对于肝功能异常原因未明且初始抗-HEV IgM阴性的中老年和免疫功能缺陷的患者,建议重新检测抗-HEV IgM,以进一步确认或排除HEV感染。
Hepatitis E virus(HEV)is a common pathogen that causes acute viral hepatitis,anti-HEV immunoglobulin M(IgM)is one of the important diagnostic indicators.In this case report,three symptomatic HEV-infected patients who were initially anti-HEV IgM negative on admission and became positive during hospitalization were reported.When anti-HEV IgM is positive,it is accompanied by a positive conversion or elevated level of anti-HEV immunoglobulin G(IgG).The clinical features of the three symptomatic HEV-infected patients suggested that in clinical practice,older patients or patients with immunodeficiency status who had abnormal liver function with unknown causes and anti-HEV IgM negative on admission were recommended to undergo retesting of the serum anti-HEV IgM to further confirm or exclude HEV infection.
作者
邓浩辉
梁淑珍
刘惠媛
Deng Haohui;Liang Shuzhen;Liu Huiyuan(Department of Infectious Disease,The Fifth People’s Hospital of Shunde District,Foshan City(Longjiang Hospital of Shunde District,Foshan City),Guangdong Foshan 528318,China;Department of Critical Hepatology,Guangzhou Eighth People’s Hospital,Guangzhou Medical University,Guangdong Guangzhou 510000,China)
出处
《中国肝脏病杂志（电子版）》
CAS
2024年第3期69-72,共4页
Chinese Journal of Liver Diseases：Electronic Version
基金
广东省医学科学技术研究基金项目(A2024644)
佛山市卫生健康局医学科研课题(20230213)。
