摘要
目的评价长链脂酰辅酶A合成酶4(acyl-CoA synthetase long-chain family member 4,ACSL4)对肝癌患者预后的影响。方法系统检索PubMed、Embase、Cochrane Library、Web of science、中国知网、万方医学与维普数据库,检索时间均从建库至2023年2月,收集ACSL4表达对肝癌患者预后影响的队列研究。文献的筛选过程由2名评估员自主完成。将纳入的研究依据纽卡斯尔-渥太华质量评价量表(Newcastle Ottawa Scale,NOS)进行质量评估,提取文献中肝癌患者的临床病理特征、研究的结局指标及HR(95%CI)等相关数据。运用Stata17.0MP软件对文献数据进行统计分析,采用漏斗图与Egger’s检验探讨偏倚风险。结果共纳入6项队列试验(890例肝癌患者)。Meta分析表明,与ACSL4低表达组患者相比,ACSL4高表达组肝癌患者总生存期(overall survival,OS)较短(HR=1.274,95%CI:1.141~1.422,P<0.001);肝癌患者中,男性ACSL4高表达(OR=1.12,95%CI:1.008~1.224,P<0.05)。Egger’s检验表明研究间存在发表偏倚的可能性较小(P=0.055)。ACSL4表达水平与年龄、肿瘤分期、肿瘤大小和肿瘤包膜是否完整以及是否合并肝硬化的相关性无统计学意义(P均>0.05)。结论ACSL4高表达与肝癌患者较短OS的相关性具有统计学意义,但仍需要更多的高质量临床研究进行验证。
Objective To systematically review and compare the effects of acyl-CoA synthetase long-chain family member 4(ACSL4)on the prognosis of patients with liver cancer.Methods Systematic searches were conducted in PubMed,Embase,Cochrane Library,Web of Science,CNKI,Wanfang Medical and VIP databases from inception to February 2023 to collect cohort studies that explored the impact of ACSL4 expression on the prognosis of patients with liver cancer.The literature screening was performed independently by two evaluators.The quality of eligible studies were evaluated according to the Newcastle Ottawa Scale(NOS)and relevant data including clinical and pathological characteristics of liver cancer patients,outcome indicators and HR(95%CI)of the study etc.were extracted.Statistical analysis of data from the literature was performed using stata 17.0 software.The risk of bias was assessed using funnel plots and Egger’s test.Results Six cohort trials with a total of 890 liver cancer patients were included.Meta-analysis showed that liver cancer patients with an increased ACSL4 expression had shorter overall survival(OS)(HR=1.274,95%CI:1.141~1.422,P<0.001).The ACSL4 expression in male patients with liver cancer was higher than those in female patients(OR=1.12,95%CI:1.008~1.224,P<0.05).Egger’s test showed that the likelihood of publication bias between studies was small and not statistically significant(P=0.055).Besides,age,tumor stage,tumor size,tumor envelope integrity and appearance of cirrhosis were not significantly correlated with the expression level of ACSL4(all P>0.05).Conclusions High ACSL4 expression was significantly associated with shorter OS in patients with liver cancer,more high-quality clinical studies were needed to validate this conclusion.
作者
王玉琪
王鹏
刘辉
王昕
易雲雲
李鑫
Wang Yuqi;Wang Peng;Liu Hui;Wang Xin;Yi Yunyun;Li Xin(Center for Integrative Medicine,Beijing Ditan Hospital,Capital Medical University,Beijing 100015,China;Center for Integrative Medicine,Peking University Ditan Teaching Hospital,Beijing 100015,China)
出处
《中国肝脏病杂志（电子版）》
CAS
2024年第3期1-7,共7页
Chinese Journal of Liver Diseases：Electronic Version
基金
北京市自然科学基金资助项目(面上项目)(7212053)
国家中医药管理局创新团队和人才培养计划(ZYYCXTD-C-202006)
北京市医院管理局登峰人才支持计划(DFL20221601)。
关键词
长链脂酰辅酶A合成酶4
肝癌
预后
META分析
Acyl-CoA synthetase long-chain family member 4
Liver cancer
Prognosis
Meta-analysis
