摘要
肾脏纤维化是慢性肾脏病(CKD)进展至终末期肾病的关键病理生理过程,严重危害人类健康,其诊断、治疗和分子机制研究一直备受关注。肾脏纤维化作为多数慢性肾脏病的终末期表现,以肾功能单位受损、肾足细胞凋亡、肾小管坏死、间质成纤维细胞增殖、细胞外基质(ECM)堆积为主要病理特征,一般结合患者的临床病史、实验室检查和影像学表现等多途径诊断肾脏纤维化并施以药物治疗。多种信号通路参与肾脏纤维化的发生和发展,包括炎症反应、细胞凋亡和细胞间相互作用等。深入了解这些分子机制,有助于更有效地治疗肾脏纤维化。本研究通过对近年来肾脏纤维化诊断治疗方法及分子机制研究进行综述,以期为寻找治疗肾脏纤维化的新靶点提供依据。
Renal fibrosis is a key pathophysiological process in the progression of chronic kidney disease(CKD)to end-stage renal disease,which seriously endangers human health.The diagnosis,treatment,and molecular mechanisms of renal fibrosis have been highly concerned.As the end-stage manifestation of most chronic kidney diseases,renal fibrosis is characterized by impaired renal function units,apoptosis of renal podocytes,tubular necrosis,proliferation of interstitial fibroblasts,and accumulation of extracellular matrix(ECM).Renal fibrosis is generally diagnosed by combining patients′clinical history,laboratory tests,and imaging manifestations,and drug treatment is applied.Studies have also shown that multiple signaling pathways are involved in the occurrence and development of renal fibrosis,including the inflammatory response,apoptosis,and intercellular interactions.An in-depth understanding of these molecular mechanisms is helpful in developing more effective treatment strategies.This paper summarizes recent advances in the diagnosis,treatment and molecular mechanisms of renal fibrosis,aiming to provide a basis for identifying new targets for treatment.
作者
杨惠元
韦妙灵
牧苏婉
李勇
YANG Huiyuan;WEI Miaoling;MU Suwan;LI Yong(College of Intelligent Medicine and biotechnology,Guilin Medical University,Guilin 541199,China)
出处
《华夏医学》
CAS
2024年第5期8-15,共8页
Acta Medicinae Sinica
基金
国家自然科学地区科学基金项目(32260166)
广西科技计划青年创新人才科研专项项目(2019AC20357)
国家级大学生创新训练项目(202210601046)。
关键词
肾脏纤维化
诊断
治疗
分子机制
renal fibrosis
diagnosis
treatment
molecular mechanisms
