摘要
颞叶癫痫(TLE)是一种常见的慢性神经系统疾病,由大脑神经元大量同步化异常放电引起。尽管抗癫痫药物在多数情况下能够有效控制患者症状,但仍有约30%的TLE患者对药物产生耐药性,进而发展为难治性癫痫,因此进一步探明TLE的发病新机制尤为重要。多年来的研究表明,即早基因(IEGs)在TLE的发病过程中发挥了重要作用。这些基因通过影响神经元兴奋性/抑制性平衡、神经元死亡以及突触重构等方面,参与癫痫发生和发展。本文就几种经典的IEGs在TLE发病过程中的具体作用及其分子机制作一综述,旨在为增加对TLE发病机制的理解,并为相关临床研究提供线索。
Temporal lobe epilepsy(TLE)is a common chronic neurological disorder caused by highly synchronized abnormal discharges of neurons in the cerebral cortex.Although most epileptic symptoms can be effectively controlled by antiepileptic drugs,about 30%of patients with TLE still develop resistance to the drugs,and then develop refractory epilepsy.Thus,it is particularly important to further explore the new mechanisms underlying the molecular pathogenesis of TLE.Coverging studies have indicated that immediate early genes(IEGs)play a vital role in limbic epileptogeneis.These genes participate in the limbic epileptogeneis by altering neuronal excitability/inhibitory balance,neuronal death,and synaptic reorganization.This paper presents a comprehensive re-view of the specific roles and molecular mechanisms of several classic IEGs in the pathogenesis of TLE,aiming to enhance the understanding of the pathogenesis of TLE and provide new insights into relevant clinical research.
作者
张薇
齐淑雅
谭国鹤
ZHANG Wei;QI Shuya;TAN Guohe(Institute of Neuroscience,School of Basic Medical Sciences,Guangxi Medical University,Nanning 530021,China;Guangxi Key Laboratory of Brain Science,Nanning 530021,China;Key Laboratory of Longevity and Aging-related Diseases of Chinese Ministry of Education,Center of Translational Medicine,Guangxi Medical University,Nanning 530021)
出处
《广西医科大学学报》
CAS
2024年第10期1442-1448,共7页
Journal of Guangxi Medical University
基金
国家自然科学基金资助项目(No.82060253)。
关键词
即早基因
颞叶癫痫
发病机制
神经元凋亡
癫痫发生
immediate early genes
temporal lobe epilepsy
pathogenesis
neuronal apoptosis
epileptogenesis
