摘要
目的考察参术健脾增食汤对小儿厌食症患者的临床疗效。方法176例患者随机分为对照组和观察组,每组88例,对照组给予复方胃蛋白酶颗粒,观察组在对照组基础上加用参术健脾增食汤,疗程21 d。检测临床疗效、中医证候评分、小儿生长和营养状况指标(身高、体质量、BMI、进食量、血红蛋白、CD4^(+)、CD8^(+))、食欲调节因子(瘦素、血管活性肽、胃动素、胃泌素、促人生长激素释放肽)、不良反应发生率、复发率变化。结果观察组总有效率高于对照组(P<0.05),复发率更低(P<0.05)。治疗后,2组中医证候评分、CD8^(+)降低(P<0.05),身高、体质量、BMI、进食量、血红蛋白、CD4^(+)、食欲调节因子升高(P<0.05),以观察组更明显(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P<0.05)。结论参术健脾增食汤可安全有效地缓解小儿厌食症患者临床症状,改善食欲及营养状态,降低复发率。
AIM To investigate the clinical effects of Shenzhu Jianpi Zengshi Decoction on infantile anorexia.METHODS One hundred and seventy-six patients were randomly assigned into control group(88 cases)for 21-day administration of Compound Pepsin Granules,and observation group(88 cases)for 21-day administration of both Shenshu Jianpi Zengshi Decoction and Compound Pepsin Granules.The changes in clinical effects,TCM syndrome scores,infantile growth and nutritional status indices(height,body weight,BMI,food intake,hemoglobin,CD4^(+),CD8^(+)),appetite regulators(leptin,vasoactive peptide,motilin,gastrin,human growth hormone releasing peptide),incidence of adverse reactions and recurrence rate were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P<0.05),along with lower recurrence rate(P<0.05).After the treatment,the two groups displayed decreased TCM syndrome scores,CD8^(+)(P<0.05),and increased height,body weight,BMI,food intake,hemoglobin,CD4^(+),appetite regulators(P<0.05),especially for the observation group(P<0.05).No significant difference in incidence of adverse reactions was found between the two groups(P>0.05).CONCLUSION For the patients with infantile anorexia,Shenzhu Jianpi Zengshi Decoction can safely and effectively alleviate clinical symptoms,improve appetite and nutritional status,and reduce recurrence rate.
作者
刘晓燕
崔尧
王海燕
赵莉
荣潇
陈英芳
LIU Xiao-yan;CUI Yao;WANG Hai-yan;ZHAO Li;RONG Xiao;CHEN Ying-fang(Department of Pediatrics,Hebei Provincial Hospital of Traditional Chinese Medicine,Shijiazhuang 050011,China;Hebei Provincial Key Laboratory for Integrated Traditional Chinese and Western Medicine in Gastroenterology Research,Shijiazhuang 050011,China;Hebei Provincial Technology Innovation Center for Traditional Chinese Medicine in Treating Spleen and Kidney Diseases,Shijiazhuang 050011,China;Hebei University of Chinese Medicine,Shijiazhuang 050000,China)
出处
《中成药》
CAS
CSCD
北大核心
2024年第10期3293-3297,共5页
Chinese Traditional Patent Medicine
基金
河北省中医药管理局科研计划项目(2023046)。
关键词
参术健脾增食汤
复方胃蛋白酶颗粒
小儿厌食症
Shenzhu Jianpi Zengshi Decoction
Compound Pepsin Granules
infantile anorexia
