摘要
EB病毒(EBV)是人类第一种肿瘤病毒,是多种上皮和淋巴源性癌症的致病因子。EBV的生命周期包括潜伏期和裂解期两个阶段。裂解周期是新病毒颗粒产生的阶段,而潜伏周期则是一种持续感染的状态,不会产生有效的病毒复制。目前的观点认为,潜伏期基因是EBV相关癌症发病机制的关键驱动因素,而裂解期基因主要负责病毒传播。然而,近年来的证据表明,EBV的裂解阶段在EBV肿瘤发生中也发挥着重要作用,研究人员也在肿瘤组织和细胞系中检测到裂解基因的表达。本文将概述EBV裂解基因在肿瘤发生过程的促进作用,并讨论了未来可能的研究方向。
Epstein-Barr virus(EBV),the first human oncolytic virus,is the causative agent of several cancers of epithelial and lymphoid origin.The life cycle of EBV consists of two phases,the latent and lytic phases.The lytic cycle is the phase in which new virus particles are produced,whereas the latent cycle is a state of persistent infection that does not result in efficient viral replication.The current view is that latent-phase genes are key drivers of the pathogenesis of EBV-associated cancers,whereas lytic genes are primarily responsible for viral transmission.However,recent evidence suggests that the lytic phase of EBV also plays an important role in EBV tumorigenesis,and researchers have detected the expression of lytic genes in tumor tissues and cell lines.This paper will outline the contributory role of EBV lytic genes in tumorigenesis and discuss possible future research directions.
作者
邓溢章
钟茜
DENG Yizhang;ZHONG Qian(State Key Laboratory of Oncology in South China,Sun Yat-sen University Cancer Center,Sun Yat-sen University,Guangzhou 510060,China)
出处
《广西医科大学学报》
CAS
2024年第9期1252-1260,共9页
Journal of Guangxi Medical University
关键词
EB病毒
肿瘤
裂解基因
Epstein-Barr virus
tumor
lytic genes
