摘要
目的:通过对雷公藤及其制剂的不良反应相关研究热点与趋势进行分析,以期为对今后临床安全使用雷公藤及其制剂提供参考。方法:在PubMed、Embase、the Cochrane Library、中国生物医学文献服务系统、中国知网、万方数据库、维普数据库中检索雷公藤及其制剂的不良反应相关文献(检索时间截至2024年1月),应用CiteSpace 6.2.R6软件对1996年1月至2024年1月的文献进行文献计量学和可视化分析。结果:共检索出828篇文献,按照纳入与排除标准筛选后最终纳入309篇文献。该领域相关研究的发文量总体呈现3个阶段,共出现22名核心作者,并形成了多个成员数目不等的作者合作团队。纳入的文献来源于216个机构,不同机构之间的合作情况较少,发文量排序居前10位的机构累计发表文献42篇(占13.6%),其中山东中医药大学、北京中医药大学发文量最多。分析后得到10个关键词聚类团及16个突现词。Meta分析、糖尿病肾病在近年来受到广泛关注,成为研究热点。结论:知识图谱显示雷公藤及其制剂的不良反应相关研究呈现出平稳发展的现状,但各机构之间的合作不紧密,有待进一步加强,研究主要集中在临床应用、临床疗效等热点领域,为后续对雷公藤及其制剂不良反应的进一步研究提供了思路。
OBJECTIVE:To analyze the research hot spot and trend of adverse drug reactions of Tripterygii radix and its preparations,so as to provide reference for the safe use of Tripterygii radix and its preparations in the future.METHODS:PubMed,Embase,the Cochrane Library,SinoMed,CNKI,Wanfang Data and VIP database were retrieved to collect relevant literature on adverse drug reactions of Tripterygii radix and its preparations(the retrieval time was up to Jan.2024).CiteSpace 6.2.R6 software was applied to perform bibliometric and visual analysis of the literature from Jan.1996 to Jan.2024.RESULTS:A total of 828 articles were retrieved,and 309 articles were finally included according to the inclusion and exclusion criteria.The overall number of publications of related studies in this field showed three phases,with a total of 22 core authors and multiple collaborative teams of authors with varying numbers of members.The included literature originated from 216 institutions,with less collaboration among different institutions.The top ten institutions in terms of the number of publications accumulated a total of 42 articles(13.6%),with Shandong University of Traditional Chinese Medicine and Beijing University of Traditional Chinese Medicine had the largest number of publications.After analysis,10 keyword clusters and 16 emergent words were obtained.Meta-analysis,diabetic kidney disease had received widespread attention as the research hot spot in recent years.CONCLUSIONS:The knowledge graph presents the status quo of the smooth development of the research on adverse drug reactions of Tripterygii radix and its preparations,yet the cooperation among different institutions is not close and needs to be further strengthened,and the research mainly focuses on the hot spot areas such as clinical application and clinical efficacy,which provides ideas for the follow-up of further research on the adverse drug reactions of Tripterygii radix and its preparations.
作者
刘诗琪
庄健
蔡良音
苟小军
LIU Shiqi;ZHUANG Jian;CAI Liangyin;GOU Xiaojun(Central Laboratory,Baoshan Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201999,China;Dept.of Orthopedics,Shanghai Qingpu District Zhujiajiao People’s Hospital,Shanghai 201713,China;Dept.of Pharmacy,Zhongshan Hospital Wusong Branch,Fudan University,Shanghai 200940,China)
出处
《中国医院用药评价与分析》
2024年第10期1262-1266,共5页
Evaluation and Analysis of Drug-use in Hospitals of China
基金
上海市2023年度“科技创新行动计划”自然科学基金面上项目(No.23ZR1447600)。
