摘要
目的探讨右美托咪定应用于ICU重症脓毒血症患者镇静中的疗效。方法非随机选取2022年4月—2023年7月贵阳市第二人民医院ICU收治的68例重症脓毒血症患者作为研究对象,按治疗方法不同分为两组,各34例。对照组使用咪达唑仑,观察组使用右美托咪定。对比两组患者的血流动力学指标、呼吸参数指标、镇定效果。结果麻醉2 h后,观察组收缩压为(120.12±9.83)mmHg、舒张压为(85.39±6.57)mmHg、心率为(63.52±8.48)次/min,均低于对照组的(128.42±8.16)mmHg、(102.46±7.53)mmHg、(70.53±9.54)次/min,差异有统计学意义(t=3.788、9.967、3.202,P均<0.05)。麻醉2 h后,与对照组相比,观察组呼吸频率、血氧饱和度更高,气道峰压更低,差异有统计学意义(P均<0.05)。观察组镇静时间、唤醒时间均短于对照组,差异有统计学意义(P均<0.05)。结论对于ICU中的重症脓毒血症患者,采用右美托咪啶治疗,能够显著优化其呼吸指标,提升镇静疗效,同时有效维持血液动力学稳定状态。
Objective To investigate the effect of dexmedetomidine on sedation in patients with severe sepsis in ICU.Methods Sixty-eight patients with severe sepsis admitted to the ICU of Guiyang Second People's Hospital from April 2022 to July 2023 were non-randomly selected as the study subjects.They were divided into two groups according to different treatment methods,with thirty four patients in each group.The control group was treated with midazolam,and the observation group was treated with dexmedetomidine.The hemodynamic indexes,respiratory parameters and stabilization effects of the two groups were compared.Results After 2 hours of anesthesia,the systolic blood pressure score was(120.12±9.83)mmHg,the diastolic blood pressure score was(85.39±6.57)mmHg,and the heart rate score was(63.52±8.48)times/min in the observation group,lower than(128.42±8.16)mmHg,(102.46±7.53)mmHg,(70.53±9.54)times/min in the control group,and the differences were statistically significant(t=3.788,9.967,3.202,all P<0.05).After 2 hours of anesthesia,compared with the control group,the respiratory rate and blood oxygen saturation of the observation group were higher,and the airway peak pressure was lower,the differences were statistically significant(all P<0.05).The sedation time and wake-up time of the observation group were shorter than those of the control group,and the differences were statistically significant(both P<0.05).Conclusion For patients with severe sepsis in ICU,dexmedetomidine treatment can significantly optimize their respiratory indicators,improve sedative efficacy,and effectively maintain hemodynamic stability.
作者
张誉耀
刘廷
刘宇峰
ZHANG Yuyao;LIU Ting;LIU Yufeng(Department of Respiratory and Critical Care Medicine,Guiyang Second People's Hospital,Guiyang 550081,Guizhou,China)
出处
《系统医学》
2024年第18期39-42,共4页
Systems Medicine
