摘要
慢性疲劳综合征(CFS)作为一组症候群,其特点是身体因长期的疲劳而引起的严重机能失调。对于其发病的具体原因尚未解,发病机制复杂,经过多年的研究探讨,发现该病的发生发展与病毒感染、神经内分泌、应激、免疫与遗传等因素关系密切。本文以大脑为着眼点,将从大脑结构功能的改变、应激反应和中枢神经递质的水平变化与CFS的关系等几个方面来探讨CFS发病与脑相关的作用机制的研究,经分析整合后,阐明CFS的发病与大脑的关系,为今后深入研究CFS发病机制提供新的切入点。
Chronic fatigue syndrome(CFS)is a group of symptoms characterized by severe dysfunctions due to chronic fatigue.The specific pathogenesis is complicated and remains unsolved.After years of research and discussion,it has been found that the occurrence and development of CFS is closely related to viral infection,neuroendocrine,stress,immunity and genetics.Focusing on the brain,this paper discussed the pathogenic mechanism of CFS and the brain from the aspects of changes in brain structure and function,stress response and the relationship between the level of central neurotransmitters and CFS.Through a thorough analysis,the relationship between the pathogenesis of CFS and brain was clarified,thus providing a new entry point for a further study on the pathogenesis of CFS.
作者
王慧芳
徐小珊
王一晓
翟春涛
WANG Huifang;XU Xiaoshan;WANG Yixiao(Shanxi University of Chinese Medicine,Shanxi,Taiyuan 030619,China)
出处
《河北医药》
CAS
2024年第20期3158-3162,共5页
Hebei Medical Journal
基金
山西省自然科学研究面上项目(编号:202203021211224)
山西省高等学校人文社会科学重点研究基地项目(编号:20190127)
山西中医药大学“临床科研平台建设”项目(编号:2021PY-PT-02)。
关键词
慢性疲劳综合征
发病机制
应激反应
HPA轴
中枢神经递质
chronic fatigue syndrome(CFS)
pathogenesis
stress reaction
hypothalamic-pituitary-adrenal(HPA)axis
central neurotransmitter
