摘要
综述苍术健脾、燥湿的作用机制及研究进展。古代医家常用苍术治疗多种疾病的脾胃湿证。苍术有效成分能改善胃排空及小肠推进率;可增加胃泌素、胃动素等,促进胃酸分泌,增加胃肠动力;可降低血管活性肠肽水平,抑制肠蠕动亢进。苍术能双向调节胃肠功能紊乱,且还能改善胃黏膜的异常形态,减轻胃组织损伤,改善肠组织异常结构。苍术燥湿的主要有效成分为挥发油,可导致体液丢失,血黏度增加,影响唾液腺分泌,引起口干,降低肾脏水通道蛋白2的表达量。苍术及其提取物能降低大鼠胃、大肠、尿液中水通道蛋白含量,通过多脏器调节体内水液代谢。故苍术能从影响脏器形态、胃肠道激素水平、水通道蛋白表达等多方面达到健脾、燥湿的功效。
Mechanism and research progress of Atractylodis Rhizoma tonifying spleen and resolving dampness is reviewed.Ancient physicians often used Atractylodis Rhizoma to treat various diseases related to spleen and stomach dampness.The components of Atractylodis Rhizoma can improve gastric emptying and small intestine propulsion rate,also can increase gastrin and motilin,and promote gastric acid secretion and enhance gastrointestinal motility.Moreover,it can decrease vasoative intestinal peptide levels and inhibit excessive intestinal peristalsis.Atractylodis Rhizoma can regulate gastrointestinal dysfunction in a bidirectional manner.It can improve abnormal morphology of gastric mucosa.It also can reduce gastric tissue injury and improve abnormal structure of intestinal tissue.The main effective component of Atractylodis Rhizoma in resolving dampness is volatile oil,which can lead to fluid loss,increased blood viscosity,affect salivary gland secretion,cause dry mouth,and decrease the expression of aquaporin 2 in the kidney.Atractylodis Rhizoma and its extracts can reduce the content of aquaporin in the stomach,colon,and urine of rats,regulating fluid metabolism in multiple organs.Therefore,Atractylodis Rhizoma achieves the effects of tonifying spleen and resolving dampness from various aspects such as organ morphology,gastrointestinal hormone level,and aquaporin expression.
作者
金昕
陈清光
侯瑞芳
陶乐维
徐佩英
陆灏
JIN Xin;CHEN Qingguang;HOU Ruifang;TAO Lewei;XU Peiying;LU Hao(Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)
出处
《上海中医药杂志》
CSCD
2024年第10期95-101,共7页
Shanghai Journal of Traditional Chinese Medicine
基金
国家自然科学基金项目(82074381,81874434)
上海市卫健委临床重点专科项目(shslczdzk05401)
上海市科委中医临床重点实验室项目(20DZ2272200)
上海市中管局长三角中医内分泌代谢病专科联盟项目(ZY[2021-2023]-0302)。
关键词
苍术
健脾
燥湿
脾虚湿阻证
作用机制
中药研究
Atractylodis Rhizoma
tonifying spleen
resolving dampness
spleen deficiency dampness obstruction syndrome
mechanism of action
traditional Chinese herbal medicine research
