摘要
目的:优化复方石斛黄精颗粒剂提取及成型工艺。方法:以多糖提取率为指标,优化复方石斛黄精颗粒提取工艺,以颗粒成型率、休止角、吸湿性和溶化性为指标,研究最优成型工艺。结果:复方石斛黄精颗粒最佳提取工艺为料液比为1∶23(g/mL)、提取温度为76.8℃、提取时间为132.3 min。最佳成型工艺为乳糖与糊精的比例为2.38∶1;赋形剂与浸膏的比例为3.36∶1。结论:优选的提取及成型工艺稳定可靠,为复方石斛黄精颗粒剂实现工业生产提供理论依据。
Objective:The extraction process and preparation technology of Compound Dendrobium Polygonatum sibiricum Granules were optimized.Methods:The extraction rate of polysaccharide was used as the index to optimize the extraction process of Compound Dendrobium Polygonatum sibiricum Granules,and preparation technology was evaluated with the inspection index of hygroscopicity,solubility,molding rate,and angle of repose.Results:The optimal extraction process were as follows:solid to liquid ratio 1∶23(g/mL),time 132.3 min,temperature 76.8℃.The optimal preparation process were lactose to dextrin ratio of 2.38∶1,the ratio of excipients to extract was 3.36∶1.Conclusion:The experiment showed that the optimized preparation techniques were stable and reliable,which provided a reliable basis for the industrial production of Compound Dendrobium Polygonatum sibiricum Granules.
作者
陈艳君
程君悦
李芳
陈存武
刘东
Chen Yanjun;Cheng Junyue;Li Fang;Chen Cunwu;Liu Dong(Generic Technology Research Center for Anhui Traditional Chinese Medicine Industry,Lu'an 237012,China;College of Biological and Pharmaceutical Engineering,West Anhui University,Lu'an 237012,China;Traditional Chinese Medicine Institute of Anhui Dabie Mountain,Lu'an 237012,China)
出处
《中国野生植物资源》
CSCD
2024年第10期59-67,共9页
Chinese Wild Plant Resources
基金
安徽省现代中药产业共性技术研究中心开放课题(AHTCMGTRC-2023-2)
西山药库研究院建设发展项目(0045021006)。
关键词
黄精
提取工艺
成型工艺
星点设计-响应面法
Polygonatum sibiricum Red.
Extraction technology
Molding technology
Central composite design-response surface method
