摘要
目的:分析支架取栓术与血栓抽吸术联合治疗老年颅内大血管急性闭塞患者的临床效果。方法:选取2021年1月—2023年10月在浙江中医药大学衢州市人民医院接受治疗的老年颅内大血管急性闭塞患者100例,随机分为对照组与治疗组,各50例。对照组接受支架取栓术治疗,治疗组接受支架取栓术联合血栓抽吸术治疗。对比两组治疗效果、并发症、颈动脉血流速度、凝血功能、血清学指标。结果:治疗组治疗总有效率高于对照组(P=0.022)。治疗组皮下积液、脑脊液漏、颅内血肿发生率均低于对照组(P<0.05)。术后3 d,两组收缩期峰值血流速度、平均血流速度均高于手术前,治疗组均高于对照组(P<0.05)。术后3 d,两组凝血酶原时间、活化部分凝血活酶时间高于手术前,纤维蛋白原水平低于手术前,治疗组优于对照组(P<0.05)。术后3 d,两组丙二醛水平低于手术前,治疗组低于对照组;两组超氧化物歧化酶水平高于手术前,治疗组高于对照组(P<0.05)。结论:支架取栓术与血栓抽吸术联合治疗老年颅内大血管急性闭塞的效果较好,可以减少并发症发生率,提高颈动脉血流速度,改善凝血功能,减轻氧化应激反应,保护血管内皮细胞功能。
Objective:To analyze the clinical effect of combined stent thrombectomy and thrombus aspiration in treating elderly patients with acute occlusion of intracranial great blood vessels.Methods:One hundred cases of elderly patients with acute occlusion of intracranial great blood vessels who received treatment in Quzhou People's Hospital of Zhejiang Chinese Medicine University from January 2021 to October 2023 were selected and randomly divided into the control group and the treatment group,fifty cases each.The control group was treated with stent thrombectomy,and the treatment group was treated with stent thrombectomy combined with thrombus aspiration.Comparison of treatment effect,complications,carotid artery blood flow velocity,coagulation function,serologic indexes of the two groups.Results:The total effective rate of treatment in the treatment group was higher than that in the control group(P=0.022).The incidence of subcutaneous effusion,cerebrospinal fluid leakage,and intracranial hematoma in the treatment group was lower than that in the control group(P<0.05).3 d postoperatively,the peak systolic blood flow velocity and the average blood flow velocity of the two groups were higher than that before the operation,and both of them were higher than that of the control group in the treatment group(P<0.05).3 d postoperatively,the prothrombin time and activated partial thromboplastin time of both groups were higher than before surgery,and the fibrinogen level was lower than before surgery,and the treatment group was better than the control group(P<0.05).3 d postoperatively,the malondialdehyde level of both groups was lower than before surgery,and the treatment group was lower than the control group;the superoxide dismutase level of both groups was higher than before surgery,and the treatment group was higher than the control group(P<0.05).Conclusion:The combined treatment of acute occlusion of intracranial great blood vessels in the elderly with stent thrombectomy and thrombus aspiration is more effective,which can r
作者
周日成
李杨波
Zhou Richeng;Li Yangbo(Department of Neurosurgery,Quzhou People's Hospital of Zhejiang Chinese Medicine University,Hangzhou 310053,Zhejiang Province,China)
出处
《中外医药研究》
2024年第25期27-29,32,共4页
JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH
关键词
颅内大血管急性闭塞
血栓抽吸术
支架取栓术
颈动脉血流速度
Acute occlusion of intracranial great blood vessels
Thrombus aspiration
Stent thrombectomy
Carotid artery blood flow velocity
