摘要
目的探讨超前镇痛在分娩镇痛中的临床应用效果.方法此研究选取2021年7月-2023年8月在我院并拟进行自然分娩的200例孕产妇作为研究对象,按照随机数字表法将所有孕产妇分为A组(0ml纳布啡,50例)、B组(0.1mg/kg纳布啡,50例)、C组(0.15mg/kg纳布啡,50例)和D组(0.2mg/kg纳布啡,50例);对四组临床效果进行对比分析.结果T0时间点各组孕产妇VAS评分差异不显著(P>0.05),T1-T5时间点B组、C组、D组孕产妇VAS评分均显著低于A组(P<0.05),T1-T5时间点C组、D组孕产妇VAS评分均显著低于B组(P<0.05),T1-T5时间点C组、D组孕产妇VAS评分比较,差异不显著(P>0.05).T0时间点各组孕产妇镇静满意度无明显差异(P>0.05),T1、T2时间点B组、C组、D组孕产妇镇静满意度均显著优于A组(P<0.05);T3-T5时间点A组、B组、C组孕产妇镇静满意度比较,差异不显著(P>0.05),T3-T5时间点D组孕产妇镇静满意度显著低于A组、B组、C组(P<0.05).分娩前四组孕产妇NGF、TNF-α、PGE2水平比较,差异不显著(P>0.05),分娩后四组孕产妇NGF、TNF-α、PGE2水平均显著低于分娩前(P<0.05);分娩后B组、C组、D组孕产妇NGF、TNF-α、PGE2水平均显著低于A组(P<0.05),C组、D组孕产妇NGF、TNF-α、PGE2水平均显著低于B组(P<0.05),C组、D组孕产妇NGF、TNF-α、PGE2水平比较,差异不显著(P>0.05).四组孕产妇第一产程时间、第二产程时间、新生儿Apgar评分及不良反应发生率比较,差异均不显著(P>0.05).结论0.15mg/kg纳布啡超前分娩镇痛安全有效,可推广应用.
Objective To investigate the clinical application effect of preemptive analgesia in labor analgesia.Methods This study selected 200 pregnant women who were hospitalized in our hospital from July 2021 to August 2023 and planned to have natural childbirth as the research objects,and divided them into group A(0ml Nalbuphine,50 cases),group B(0.1mg/kg Nalbuphine,50 cases),group C(0.15mg/kg Nalbuphine,50 cases)and group D(0.2mg/kg Nalbuphine,50 cases)according to random number table method.The clinical effects of the four groups were compared and analyzed.Results There was no significant difference in VAS scores among all groups at T0 time point(P>0.05),the VAS scores in groups B,C and D at T1-T5 time point were significantly lower than those in group A(P<0.05),the VAS scores in groups C and D at T1-T5 time point were significantly lower than those in group B(P<0.05).There was no significant difference in VAS scores between groups C and D at T1-T5 time point(P>0.05).There was no difference in sedation satisfaction among all groups at T0 time points(P>0.05),and sedation satisfaction in groups B,C and D at T1 and T2 time points was significantly better than that in group A(P<0.05).There was no significant difference in sedation satisfaction among groups A,B and C at T3-T5 time point(P>0.05),and the satisfaction of sedation in group D was significantly lower than that in groups A,B and C at T3-T5 time point(P<0.05).There were no significant differences in the levels of NGF,TNF-αand PGE2 in the four groups before delivery(P>0.05),and the levels of NGF,TNF-αand PGE2 in the four groups after delivery were significantly lower than those before delivery(P<0.05).After delivery,the levels of NGF,TNF-αand PGE2 in groups B,C and D were significantly lower than those in group A(P<0.05),and the levels of NGF,TNF-αand PGE2 in groups C and D were significantly lower than those in group B(P<0.05).There were no significant differences in NGF,TNF-αand PGE2 levels between C and D groups(P>0.05).There were no significant differences
作者
赵翠
张涣君
张涛
邵晓青
张绪东
Zhao Cui;Zhang Huanjun;Zhang Tao;Shao Xiaoqing;Zhang Xudong(Weifang Maternal and Child Health Hospital,Weifang,Shandong 261205,China)
出处
《首都食品与医药》
2024年第20期37-40,共4页
Capital Food Medicine
基金
潍坊市卫生健康委科研项目(WFWSJK-2021-169)。
关键词
分娩镇痛
超前镇痛
纳布啡
labor analgesia
Preemptive analgesia
nalbuphine
