摘要
目的探究固本咳喘颗粒治疗老年慢性阻塞性肺疾病(COPD)伴下呼吸道细菌感染(LRTBI)的临床效果。方法应用随机对照试验设计,选取2022年7月至2023年7月商丘市梁园区中医医院收治的104例老年COPD伴LRTBI患者,采用随机数表法分为观察组和对照组各52例。对照组患者给予常规对症治疗,观察组患者于对照组基础上联合固本咳喘颗粒治疗,两组均治疗2周。比较两组患者的治疗效果以及治疗前后不同时间的痰液病原菌清除率和肺功能指标、TLR4/NF-κB信号通路因子(TLR4、NF-κB蛋白)水平、T淋巴细胞亚群(CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+))、炎性因子,同时比较两组患者治疗期间的不良反应发生率。结果观察组患者的治疗总有效率为94.23%,明显高于对照组的80.77%,差异有统计学意义(P<0.05);观察组患者治疗1周、2周后的痰液病原菌清除率分别为65.38%、96.15%,明显高于对照组的44.23%、82.69%,差异均有统计学意义(P<0.05);治疗1周、2周后,观察组患者的用力肺活量(FVC)、第1秒用力呼气量(FEV1)、最大呼气流量(PEF)分别为(2.59±0.22)L、(2.27±0.32)L、(3.19±0.46)L/s和(2.68±0.25)L、(2.41±0.34)L、(3.56±0.51)L/s,明显高于对照组的(2.40±0.21)L、(1.96±0.28)L、(2.73±0.48)L/s和(2.47±0.23)L、(2.05±0.31)L、(3.08±0.53)L/s,差异均有统计学意义(P<0.05);治疗1周、2周后,观察组患者的外周血TLR4、NF-κB蛋白水平分别为0.68±0.15、0.66±0.15和0.57±0.12、0.54±0.13,明显低于对照组的0.77±0.17、0.75±0.14和0.69±0.15、0.67±0.14,差异均有统计学意义(P<0.05);治疗1周、2周后,观察组患者的外周血CD3^(+)、CD4^(+)阳性细胞比例及CD4^(+)/CD8^(+)分别为(66.07±3.65)%、(42.55±2.73)%、1.76±0.24和(68.54±3.26)%、(44.21±2.86)%、1.83±0.25,明显高于对照组的(62.54±3.71)%、(40.61±2.81)%、1.60±0.25和(65.17±3.49)%、(41.93±2.79)%、1.69±0.23,差异均有统计学意义(P<0.05);治疗1周、2周后,观察组患者�
Objective To explore the clinical effect of Guben Kechuan Granules in the treatment of elderly patients with chronic obstructive pulmonary disease(COPD)accompanied by lower respiratory tract bacterial infection(LRTBI).Methods A randomized controlled trial design was applied,and 104 elderly patients with COPD and LRTBI who were admitted to the Liangyuan Hospital of Traditional Chinese Medicine from July 2022 to July 2023 were selected.The patients were randomly divided into a study group and a control group using a random number table method,with 52 patients in each group.Patients in the control group received conventional symptomatic treatment,while those in the study group were treated with Guben Kechuan Granules in addition to the treatment in the control group.Both groups of patients were treated for 2 weeks.The treatment effects were compared between the two groups,as well as clearance rates of pathogenic bacteria in sputum and lung function indicators,TLR4/NF-κB signaling pathway factors(TLR4,NF-κB protein)levels,and T lymphocyte subsets(CD3^(+),CD4^(+),CD4^(+)/CD8^(+)),inflammatory factors before and after the treatment.The incidence of adverse reactions during treatment was also compared between the two groups.Results The total effective rate of the study group was 94.23%,which was significantly higher than that in the control group(80.77%),P<0.05.The clearance rates of pathogenic bacteria in sputum after one and two weeks of treatment in the study group were 65.38%and 96.15%,respectively,which were significantly higher than 44.23%and 82.69%in the control group(P<0.05).After one and two weeks of treatment,the forced vital capacity(FVC),forced expiratory volume in one second(FEV1),and peak expiratory flow(PEF)in the study group were(2.59±0.22)L,(2.27±0.32)L,(3.19±0.46)L/s and(2.68±0.25)L,(2.41±0.34)L,(3.56±0.51)L/s,respectively,which were significantly higher than(2.40±0.21)L,(1.96±0.28)L,(2.73±0.48)L/s and(2.47±0.23)L,(2.05±0.31)L,(3.08±0.53)L/s in the control group,with statistically signifi
作者
赵颖
张德振
李春燕
李志杰
ZHAO Ying;ZHANG De-zhen;LI Chun-yan;LI Zhi-jie(Department of Internal Medicine,Liangyuan Hospital of Traditional Chinese Medicine,Shangqiu 476000,Henan,CHINA;Department of Respiratory Medicine,the First People's Hospital of Shangqiu,Shangqiu 476000,Henan,CHINA)
出处
《海南医学》
CAS
2024年第20期2915-2920,共6页
Hainan Medical Journal
基金
2022年河南省医学科技攻关联合共建项目(编号:LHGJ20221861)。
关键词
慢性阻塞性肺疾病
下呼吸道细菌感染
固本咳喘颗粒
疗效
肺功能
TLR4/NF-κB信号通路
T淋巴细胞亚群
Chronic obstructive pulmonary disease
Lower respiratory tract bacterial infection
Guben Kechuan Granules
Therapeutic effect
Lung function
TLR4/NF-κB signaling pathway
T-lymphocyte subsets
