摘要
目的探讨全身免疫炎症指数(SII)与牙周炎分级诊断的相关性。方法按照纳入及排除标准,对2023年1—10月于长沙市口腔医院就诊患者进行筛选,共选择263人,分为牙周炎组(131例)和牙周健康组(132例),分析两组间SII、中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)、淋巴细胞与单核细胞比值(LMR)的差异。采用Logistic回归分析法和受试者操作特性曲线(ROC)分析牙周炎的患病相关因素及诊断价值,用Spearman相关分析评估血细胞指标与牙周炎分级的相关性。结果与牙周健康组相比,牙周炎组SII、NLR、PLR明显升高,LMR明显降低(P<0.05)。SII、NLR、PLR、LMR均对牙周炎有预测价值,其中SII约登指数最大,价值优于NLR、PLR、LMR。Logistic回归分析显示SII、NLR与牙周炎有相关性且有统计学意义(P<0.05)。牙周炎组各分级间SII、NLR、PLR、LMR的差异均有统计学意义(P<0.05)。牙周炎分级与SII、NLR、PLR呈正相关,与LMR呈负相关(P<0.05)。结论SII与牙周炎分级存在相关性,在临床评估牙周炎进展速度方面可能具有一定的预测价值。
Objective This study aimed to investigate the correlation between the systemic immune-inflammatory in-dex(SII)and the diagnosis of periodontitis grading.Methods According to the inclusion and exclusion criteria,patients who attended Changsha Stomatological Hospital from January to October 2023 were screened and divided into the perio�dontitis group(131 patients)and the periodontal health group(132 patients).The differences in SII,neutrophil to lympho-cyte ratio(NLR),platelet to lymphocyte ratio(PLR),and lymphocyte to monocyte ratio(LMR)were analyzed between the two groups.We used Logistic regression analysis and receiver operating characteristic curve to analyze the factors re-lated to the prevalence and diagnostic value of periodontitis.Spearman correlation analysis was conducted to determine the correlation between blood cell indicators and pe�riodontitis grading.Results SII,NLR,and PLR were significantly higher and LMR was significantly lower in the periodontitis group compared with the periodontal health group(P<0.05).SII,NLR,PLR,and LMR all had a predictive value for periodontitis,with SII having the greatest Youden index and a better value than NLR,PLR,and LMR.Logistic regression analysis showed that SII and NLR were significantly correlated with periodontitis.We observed a significant difference in SII,NLR,PLR,and LMR among the grades in the periodontitis group(P<0.05).Periodontitis grading was positively correlated with SII,NLR,and PLR but negatively correlated with LMR.Conclusion We found a correlation between SII and periodontitis grading,which may be of clinical value in the assessment of disease progression rate.
作者
陈梦洁
徐文华
刘青青
康毓聃
刘蓉
朱丽雷
Chen Mengjie;Xu Wenhua;Liu Qingqing;Kang Yudan;Liu Rong;Zhu Lilei(School&Hospital of Stomatology,Hunan University of Chinese Medicine,Changsha 410208,China;Dept.of Perio�dontal Mucosa,Changsha Stomatological Hospital,Changsha 410004,China)
出处
《国际口腔医学杂志》
CAS
CSCD
北大核心
2024年第6期706-712,共7页
International Journal of Stomatology
基金
湖南省卫生健康委科研计划项目(202208013498,D2023-08017691)
湖南中医药大学本科生科研创新基金(2023BKS141)。
关键词
牙周炎
分级
全身免疫炎症指数
periodontitis
grading
systemic immune-inflammatory index
