摘要
皮肌炎是一种病因不明的自身免疫性疾病,主要累及皮肤和肌肉,表现为典型皮损、近端肌无力和多器官受累,亦可伴发恶性肿瘤。由于皮肌炎较罕见,早期临床表现不明显,极易延误治疗。早期明确诊断并采用激素及免疫抑制剂等药物治疗可延缓疾病进展。皮肌炎患者自身抗体与患者的临床表现、并发症、治疗反应和预后均具有一定相关性,某些自身抗体的表达与疾病的发生、病情活动程度及严重程度有关。肌炎抗体谱是皮肌炎患者预后、临床管理及后期随访的重要指标,全面了解肌炎抗体谱与皮肌炎的相关性,可以为疾病的治疗提供有利支持。
Dermatomyositis is an autoimmune disease of unknown etiology,mainly involving skin and muscle,characterized by typical skin lesions,proximal muscle weakness,multiple organ involvement,and may also be accompanied by malignant tumors.Because dermatomyositis is rare,and the early clinical manifestations are not obvious,it is easy to delay the treatment.Early diagnosis and treatment with drugs such as hormones and immunosuppressants can delay disease progression.Autoantibodies in patients with dermatomyositis have certain correlation with clinical manifestations,complications,treatment response and prognosis.The expression degree of some autoantibodies is related to the occurrence,activity and severity of the disease.Myositis antibody spectrum is an important indicator of prognosis,clinical management and follow-up of patients with dermatomyositis.A comprehensive understanding of the correlation between myositis antibody spectrum and dermatomyositis can provide favorable support for the treatment of the disease.
作者
潘佳
帕丽达·阿布利孜
PAN Jia;PALIDA Abulizi(Department of Dermatology,the First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,China)
出处
《医学综述》
CAS
2024年第22期2756-2760,共5页
Medical Recapitulate
关键词
皮肌炎
肌炎抗体谱
临床特征
预后
Dermatomyositis
Myositis antibody spectrum
Clinical features
Prognosis
