摘要
目的 探讨中西医结合疗法对脑卒中后睡眠障碍患者的治疗效果,分析其在临床中的应用价值,为优化治疗方案提供科学依据。方法 从2022年1月—2022年6月河南中医药大学第一附属医院脑病科收治脑卒中伴睡眠障碍患者100例,将其中50例行单纯西药治疗的患者纳入对照组,另50例实施中西医结合治疗的患者归为研究组,比较整体效果。结果 治疗后7 d、15 d、30 d两组睡眠效率逐渐升高,治疗组较对照组改善更佳(P<0.05);治疗后,两组血清神经营养因子-3(NT-3)、5-羟色胺(5-HT)水平均治疗前显著降低,血清脑源性神经营养因子(BDNF)水平显著升高(P<0.05);治疗后,研究组患者血清NT-3、5-HT水平及BDNF水平均较对照组改善更佳(P<0.05);治疗后7 d、15 d、30 d,两组匹兹堡睡眠质量指数(PSQI)评分逐渐降低,治疗组低于对照组(P<0.05);治疗后7 d、15 d、30 d,两组简明健康调查问卷(SF-36)评分随时间延长随之升高,治疗组高于对照组(P<0.05);治疗组不良反应发生率为2.00%,低于对照组16.00%(P<0.05)。结论 脑卒中伴睡眠障碍患者用中西医结合治疗,不仅对睡眠质量、神经功能有积极意义,还能降低不良反应,可行性强,应用价值高。
Objective To investigate the therapeutic efficacy of an integrated approach combining traditional Chinese medicine and Western medicine therapy for post-stroke sleep disorders,analyze its clinical applicability,and provide a scientific foundation for optimizing treatment strategies.Methods A total of 100 stroke patients with sleep disorders were admitted to the Department of Encephalopathy at the First Affiliated Hospital of Henan University of Chinese Medicine from January 2022 to June 2022.Among them,the control group consisted of 50 patients treated solely with western medicine,while the study group included the other 50 patients who received integrated traditional Chinese and western medicine treatment.The overall efficacy was compared between the two groups.Results After 7 days,15 days,and 30 days of treatment,the sleep efficiency of the two groups gradually increased,and the treatment group showed better improvement than the control group(P<0.05).After treatment,the levels of serum neurotrophin-3(NT-3)and 5-hydroxytryptamine(5-HT)in both groups significantly decreased before treatment,while the levels of serum brain-derived neurotrophin factor(BDNF)significantly increased(P<0.05).After treatment,the serum levels of NT-3,5-HT,and BDNF in the study group improved significantly compared to the control group(P<0.05).After 7 days,15 days,and 30 days of treatment,the pittsburgh sleep quality index(PSQI)scores of the two groups gradually decreased,and the treatment group was lower than that in the control group(P<0.05).After 7 days,15 days,and 30 days of treatment,the scores of the two groups of short form health survey(SF-36)increased with time,and the treatment group was higher than that in the control group(P<0.05).The incidence of adverse reactions in the treatment group was 2.00%,lower than the control groups 16.00%(P<0.05).Conclusion The treatment of stroke patients with sleep disorders with integrated Chinese and western medicine not only has positive significance on sleep quality and nervous function,but a
作者
孙瑞敏
李磊
王慧利
王佳彬
SUN Rui-ming;LI Lei;WANG Hui-li;WANG Jia-bin(Department of Encephalopathy,the First Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450000,China)
出处
《医药论坛杂志》
2024年第17期1831-1835,共5页
Journal of Medical Forum
基金
河南省中医药科学研究专项课题(20-21212041)。
关键词
中西医结合
脑卒中
睡眠障碍
睡眠效率
神经功能
睡眠质量
生活质量
不良反应
Integration of traditional Chinese and western medicine
Stroke
Sleep disturbance
Sleep efficiency
Nerve function
Sleep quality
Quality of life
Adverse reaction
