摘要
背景:轻度认知障碍老年人由于认知功能下降,姿势控制能力下降,易发生跌倒。双任务范式由于更贴近日常生活,常被用于评估姿势控制能力,但以往对于轻度认知障碍老年人的认知与姿势控制双任务研究主要探讨姿势控制的外在表现特征,中枢神经机制的直接证据依然缺乏。目的:探讨轻度认知障碍老年人在执行站立姿势控制-空间工作记忆双任务时大脑躯体感觉运动皮质激活特征。方法:采用蒙特利尔认知量表(MoCA-B)筛选受试者,共纳入轻度认知障碍老年人16人、认知功能正常老年人17人,进行5种任务测试,分别为空间工作记忆(SIT)、双足平衡站立(SD)、Romberg站立(SR)、双足平衡站立-空间工作记忆双任务(DD)、Romberg站立-空间工作记忆双任务(DR);同时使用功能性近红外脑成像系统和三维测力台收集躯体感觉运动皮质(20个通道)的血液动力学、足底压力中心(COP)摆动轨迹数据。结果与结论:①在Romberg站立、双足平衡站立-空间工作记忆双任务、Romberg站立-空间工作记忆双任务下,轻度认知障碍老年人前后、内外方向足底压力中心位移均显著大于认知功能正常老年人(P<0.05);②在双足平衡站立-空间工作记忆双任务下,轻度认知障碍老年人15通道(右侧前运动皮质/辅助运动区)的氧合血红蛋白变化量值显著大于认知功能正常老年人(P<0.05);在Romberg站立-空间工作记忆双任务下,轻度认知障碍老年人15,17通道(右侧前运动皮质/辅助运动区)的氧合血红蛋白变化量值均显著大于认知功能正常老年人(P<0.05);③在Romberg站立-空间工作记忆双任务下,轻度认知障碍老年人内外方向足底压力中心位移与15通道的氧合血红蛋白变化量存在显著正相关(r=0.659,P<0.05),认知功能正常老年人内外方向足底压力中心位移与15通道的氧合血红蛋白变化量存在高度正相关(r=0.840,P<0.05)。结果表明,与认知功
BACKGROUND:Elderly people with mild cognitive impairment experience a decline in postural control ability due to cognitive function decline,making them more prone to falls.The dual-task paradigm,which more closely mirrors daily life,is often used to assess postural control ability.However,previous dual-task studies on cognition and postural control in elderly people with mild cognitive impairment have mainly focused on the external manifestations of postural control,with direct evidence of central nervous mechanisms still lacking.OBJECTIVE:To investigate the activation characteristics of the cerebral somatic sensorimotor cortex in the elderly people with mild cognitive impairment while performing the dual task of stance postural control and spatial working memory.METHODS:Participants were screened using the Montreal Cognitive Assessment,enrolling 16 elderly people with mild cognitive impairment and 17 healthy older people.They performed five task tests:spatial working memory,dual-feet balance stance,Romberg stance,dual task of dual-feet balance stance and spatial working memory,and dual task of Romberg stance and spatial working memory.Functional near-infrared spectroscopy and a three-dimentional force platform were used simultaneously to collect data on cerebral cortex(20 channels)hemodynamics and center of pressure swing trajectory.RESULTS AND CONCLUSION:In Romberg stance,dual task of dual-feet balance stance and spatial working memory,and dual task of Romberg stance and spatial working memory tasks,center of pressure displacements in anterior-posterior and medial-lateral directions were significantly greater in mild cognitive impairment elderly people than that in normal elder people(P<0.05).In dual task of dual-feet balance stance and spatial working memory task,ΔHbO_(2) at channel 15(right pre-motor cortex and supplementary motor area)was significantly greater in mild cognitive impairment elderly people than that in normal elder people(P<0.05).In dual task of Romberg stance and spatial working memory task,�
作者
董志文
于聪
陈岩
丁建军
Dong Zhiwen;Yu Cong;Chen Yan;Ding Jianjun(School of Sports and Health,Shandong Sport University,Jinan 250102,Shandong Province,China;National Football Academy and National Basketball Academy,Shandong Sport University,Rizhao 275900,Shandong Province,China)
出处
《中国组织工程研究》
CAS
北大核心
2025年第17期3579-3587,共9页
Chinese Journal of Tissue Engineering Research
基金
国家体育总局科技创新项目(23KJCX058),项目负责人:陈岩。
关键词
轻度认知障碍
姿势控制
空间工作记忆
前运动皮质
辅助运动区
功能性近红外光谱
mild cognitive impairment
postural control
spatial working memory
pre-motor cortex
supplementary motor area
functional near-infrared spectroscopy
