摘要
目的分析对气管支气管结核(TBTB)采用支气管镜下介入注药冷冻联合雾化吸入方法治疗的临床疗效。方法选取2019年5月至2023年2月南京中医药大学附属南京医院收治的TBTB 60例患者为研究对象,采用中心随机法随机分为两组各30例,对照组采用常规治疗联合雾化抗结核治疗,观察组在对照组基础上采用支气管镜下介入注药冷冻治疗。治疗3个月后比较两组患者痰菌转阴率、免疫功能相关指标[CD4^(+)、CD8^(+)、腺苷脱氨酶(ADA)]、炎症相关指标[γ-干扰素(IFN-γ)、白细胞介素-4(IL-4)、红细胞沉降率(ESR)]水平、症状缓解时间及不良反应。结果治疗3个月后,观察组患者IFN-γ、ESR水平和症状缓解时间显著低于对照组(P<0.05);痰菌转阴率、CD4^(+)、ADA和IL-4水平显著高于对照组(P<0.05)。观察组总不良反应发生率低于对照组,差异有统计学意义(10.00%vs 33.33%,χ^(2)=4.812,P<0.05)。结论支气管镜下介入注药冷冻联合雾化吸入抗结核治疗TBTB具有良好的临床疗效,可有效提高患者免疫功能,减轻其炎症反应,减少不良反应。
Objective To explore the clinical efficacy of bronchoscopic drug injection and cryotherapy combined with atomization inhalation for tracheobronchial tuberculosis(TBTB).Methods From May 2019 to February 2023,60 patients with TBTB treated in Nanjing Hospital Affiliated to Nanjing University of Chinese Medicine were selected as the study subjects,and were randomly divided into two groups with 30 cases in each group by the central randomization method.The control group received conventional thearpy combined with atomization of anti-tuberculosis treatment,while the observation group received bronchoscopic drug injection and cryotherapy of anti-tuberculosis on the basis of the control group.After 3 months of treatment,sputum negative conversion rate,immune function-related indicators[CD4^(+),CD8^(+),adenosine deaminase(ADA)],inflammation-related indicators[γ-interferon(IFN-γ),interleukin-4(IL-4),erythrocyte sedimentation rate(ESR)],symptom relief time and adverse reactions were compared between two groups.Results After 3 months of treatment,IFN-γand ESR levels,and symptom relief time in observation group were significantly lower than those in control group(P<0.05),while the sputum negative conversion rate,CD4^(+),ADA and IL-4 levels were significantly higher than those in control group(P<0.05).The incidence of total adverse reactions in observation group was lower than that in control group(10.00%vs 33.33%,χ^(2)=4.812,P<0.05).Conclusion Bronchoscopic drug injection and cryotherapy combined with atomization inhalation of anti-tuberculosis for TBTB has a good clinical efficacy,and it can effectively improve the immune function,relieve the inflammatory response,and reduce the adverse reactions in patients with TBTB.
作者
徐元龙
费贤树
田曼
XU Yuanlong;FEI Xianshu;TIAN Man(Tuberculosis Department,Nanjing Hospital Affiliated to Nanjing University of Chinese Medicine,Nanjing,Jiangsu 210000,China;不详)
出处
《中国临床研究》
CAS
2024年第10期1556-1559,共4页
Chinese Journal of Clinical Research
基金
江苏省卫生计生委科研项目(LGY2017005)。
关键词
气管支气管结核
支气管镜
注药冷冻
雾化
Tracheobronchial tuberculosis
Bronchoscopy
Drug injection and cryotherapy
Atomization
